CLUSTER

Ideally, outbreak detection should be swift in both signaling and response to prevent as many transmissible events as possible. The CLUSTER study assessed the feasibility of implementing the WHONET-SaTScan outbreak detection system and establishing a standardized outbreak response protocol within the HCA Healthcare network of hospitals. Whole genome sequencing was also performed on all available bacterial and fungal isolates identified by WHONET-SaTScan and on select isolates found with current detection methods to compare the accuracy of the detection system vs current methods. An abstract describing the results of the study was presented at IDWeek 2022, and a publication is in process.


Publications and/or Presentations

Baker MA, Sands KE, Huang SS, Kleinman K, Septimus EJ, Varma N, Blanchard J, Poland RE, Coady MH, Yokoe DS, Fraker S, Froman A, Moody J, Goldin L, Isaacs A, Kleja K, Korwek KM, Stelling J, Clark A, Platt R, Perlin JB; CDC Prevention Epicenters Program. The impact of COVID-19 on healthcare-associated infections. Clin Infect Dis ciab688. doi: 10.1093/cid/ciab688. Published online August 9, 2021, in print May 2022.

Baker MA, Septimus E, Kleinman K, Moody J, Sands K, Varma N, Isaacs A, McLean LE, Coady MH, Blanchard E, Poland R, Yokoe D, Stelling J, Haffenreffer K, Clark A, Avery TR, Sljivo S, Weinstein RA, Smith KN, Carver B, Meador B, Spencer-Smith C, Washington C, Smith K, Bhattarai M, Shimelman L, Kulldorff M, Reddy S, Jernigan JA, Perlin J, Platt R, Huang SS. CLUSTER Trial An 82 U.S. Hospital Cluster Randomized Trial (CRT) to Assess the Impact of an Automated Statistical Outbreak Detection Tool and Response Protocol to Limit Hospital Transmission. Oral Presentation October 2022 IDWeek 2022 conference.  Open Forum Infectious Diseases, Volume 9, Issue Supplement_2, December 2022, ofac492.145, https://doi.org/10.1093/ofid/ofac492.145. December 15, 2022.[PL1] 


Funder: Centers for Disease Control and Prevention