Biostatistics Publications

Publications of 2020

Rhee C, Li Z, Wang R, Song Y, Kadri SS, Septimus EJ, Chen H, Fram D, Jin R, Poland R, Sands K, Klompas M, for the CDC Prevention Epicenters Program. Impact of risk-adjustment using clinical versus administrative data on hospital sepsis mortality comparisons. Open Forum Infectious Diseases 2020, Volume 7, Issue 6, June 2020, ofaa213,

Hsu HE, Wang R, Broadwell C, Horan K, Jin R, Rhee C, Grace LM. Association between federal value-based incentive programs and healthcare-associated infections in safety-net and non-safety-net hospitals. JAMA Network Open 2020, 3(7):e209700. doi:10.1001/jamanetworkopen.2020.9700.

Chen T, Wang R. Inference for variance components in linear mixed models with flexible random effects and error distributions. Statistical Methods in Medical Research 2020, forthcoming.

Bing A, Hu Y, Prague M, Hill A, Li JZ, Bosch RJ, De Gruttola V, Wang R. Comparison of empirical and dynamic models for HIV viral load rebound after treatment interruption. Statistical Communications in Infectious Diseases 2020, forthcoming.

Zhao, L*, Chen T*, Novitsky V, Wang R. Joint penalized smoothing spline modeling of multivariate longitudinal Data, with application to modeling HIV RNA viral load levels and CD4 cell counts. Biometrics, forthcoming. *: Equal contribution.

Ogburn EL, Bierer BE, Brookmeyer R, Choirat C, Dean NE, De Gruttola V, Ellenberg SS, Halloran ME, Hanley DF, Lee JK, Wang R, Scharfstein DO. Aggregating data from COVID-19 trials. Science 2020; 368: 1198-1199.

Lutz SM, Sordillo JE, Hokanson JE, Chen Wu A, Lange C. The effects of misspecification of the mediator and outcome in mediation analysis. Genet Epidemiol. 2020 Jun;44(4):400-403. doi: 10.1002/gepi.22289. Epub 2020 Mar 13. PubMed PMID: 32166765; PubMed Central PMCID: PMC7205563. 

Chen J, Loukola A, Gillespie NA, Peterson R, Jia P, Riley B, Maes H, Dick DM, Kendler KS, Damaj MI, Miles MF, Zhao Z, Li MD, Vink JM, Minica CC, Willemsen G, Boomsma DI, Qaiser B, Madden PAF, Korhonen T, Jousilahti P, Hällfors J, Gelernter J, Kranzler HR, Sherva R, Farrer L, Maher B, Vanyukov M, Taylor M, Ware JJ, Munafò MR, Lutz SM, Hokanson JE, Gu F, Landi MT, Caporaso NE, Hancock DB, Gaddis NC, Baker TB, Bierut LJ, Johnson EO, Chenoweth M, Lerman C, Tyndale R, Kaprio J, Chen X. Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes. Nicotine Tob Res. 2020 May 26;22(6):900-909. doi: 10.1093/ntr/ntz099. PubMed PMID: 31294817; PubMed Central PMCID: PMC7249921. 

Lutz SM, Hokanson JE. The Use of Mendelian Randomization to Determine the Role of Metabolic Traits on Urinary Albumin-to-Creatinine Ratio. Diabetes. 2020 May;69(5):862-863. doi: 10.2337/dbi19-0034. PubMed PMID: 32312903; PubMed Central PMCID: PMC7171963. 

Moll M, Regan EA, Hokanson JE, Lutz SM, Silverman EK, Crapo JD, Make BJ, DeMeo DL. The Association of Multiparity with Lung Function and Chronic Obstructive Pulmonary Disease-Related Phenotypes. Chronic Obstr Pulm Dis. 2020 Apr;7(2):86-98. doi: 10.15326/jcopdf.7.2.2019.0166. PubMed PMID: 32324980. 

McGeachie MJ, Wang AL, Lutz SM, Sordillo JE, Weiss ST, Tantisira KG, Iribarren C, Lu MX, Wu AC. Real-Life Patterns of Exacerbations While on Inhaled Corticosteroids and Long-Acting Beta Agonists for Asthma over 15 Years. J Clin Med. 2020 Mar 18;9(3). doi: 10.3390/jcm9030819. PubMed PMID: 32197337; PubMed Central PMCID: PMC7141292. 

Dahlin A, Sordillo JE, McGeachie M, Kelly RS, Tantisira KG, Lutz SM, Lasky-Su J, Wu AC. Genome-wide interaction study reveals age-dependent determinants of responsiveness to inhaled corticosteroids in individuals with asthma. PLoS One.2020;15(3):e0229241. doi: 10.1371/journal.pone.0229241. eCollection 2020. PubMed PMID: 32119686; PubMed Central PMCID: PMC7051058. 

Sordillo JE, Lutz SM, Kelly RS, McGeachie MJ, Dahlin A, Tantisira K, Clish C, Lasky-Su J, Wu AC. Plasmalogens Mediate the Effect of Age on Bronchodilator Response in Individuals With Asthma. Front Med (Lausanne). 2020;7:38. doi: 10.3389/fmed.2020.00038. eCollection 2020. PubMed PMID: 32118022; PubMed Central PMCID: PMC7034309.

Rhee C, Kadri SS, Dekker JP, Danner RL, Chen HC, Fram D, Zhang F, Wang R, Klompas M; CDC Prevention Epicenters Program. Prevalence of Antibiotic-Resistant Pathogens in Culture-Proven Sepsis and Outcomes Associated With Inadequate and Broad-Spectrum Empiric Antibiotic Use. JAMA Network Open. 2020 Apr 1;3(4). PMID: 32297949

Yuhree K, Zhang F, Su K, LaRochelle M, Callahan M, Fisher D, Wharam JF, Asgari MM.

Perioperative Serum 25-Hydroxyvitamin D Levels as a Predictor of Postoperative Opioid Use and Opioid Use Disorder: A Cohort Study.  J Gen Intern Med. 2020 Jun 24 PMID 32583342.

Toh S, Rifas-Shiman SL, Lin PI, Bailey LC, Forrest CB, Horgan CE, Lunsford D, Moyneur E, Sturtevant JL, Young JG, Block JP (PCORnet Antibiotics and Childhood Growth Study Group). Privacy-protecting multivariable-adjusted distributed regression analysis for multi-center pediatric study. Pediatric Research. 2020; 87(6):1086-1092.

Young JG, Stensrud MJ, Tchetgen Tchetgen EJ, Hernán MA. A causal framework for classical statistical estimands in failure time settings with competing events. Statistics in Medicine. 2020; 39(8): 1199-1236.

Chiu Y, Rifas-Shiman SL, Kleinman K, Oken E, Young JG. Effects of intergenerational exposure interventions on adolescent outcomes: an application of inverse probability weighting to longitudinal pre-birth cohort data. Paediatric and Perinatal Epidemiology. 2020; 34(3): 366-375 

Her QL, Malenfant JM, Zhang Z, Vilk Y, Young J, Tabano DC, Hamilton J, Johnson R, Raebel MA, Boudreau DM, Toh S. Distributed regression analysis application in large distributed data networks: analysis of precision and operational performance.  Journal of Medical Internet Research. 2020; 8(6):e15073. 

Stensrud MJ, Young JG, Didelez V, Robins JM, Hernán MA. Separable effects for causal inference in the presence of competing events. Journal of the American Statistical Association. 2020 (In press). 

Young JG, Hubbard AE, Eskenazi B, Jewell NP (2020).  A machine-learning algorithm for estimating and ranking the impact of environmental risk factors in exploratory epidemiological studies.  In Almudevar A, Oakes D, Hall J (Eds.), Statistical Modeling for Biological Systems (pp.137-156). Springer Cham, Switzerland. 

Wen L, Young JG, Robins JM, Hernán MA. Parametric g-formula implementations for causal survival analyses.  Biometrics.  2020 (In press). 

Shu, D, Young JG, Toh S, Wang R. Variance estimation in inverse probability weighted Cox models.  Biometrics. 2020 (In press).

Dean NE, Gsell P, Brookmeyer R, Crawford F, Donnelly CA, Ellenberg S, Eleming T, Halloran ME, Horby P, Jaki T, Krause P, Longini IM, Nason M, Smith P, Wang R, Henao-Restrepo AM, DeGruttola V. Creating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks.  New England Journal of Medicine 2020, 382:1366-1369.

Rhee C, Kadri SS, Pekker JP, Danner RL, Chen H, Fram D, Zhang F, Wang R, Klompas M, for the CDC prevention epicenters program. Prevalence of Antibiotic-Resistant Pathogens in Culture-Proven Sepsis and Outcomes Associated with Inadequate and Broad-Spectrum Empiric Antibiotic Use. JAMA Network Open 2020, forthcoming.

Wang R, Bing A, Wang C, Bosch R, De Gruttola V. Flexible nonlinear mixed effects model for viral rebound after antiretroviral treatment interruption. Stat Med. 2020 Jul 10;39(15):2051-2066

Vinegoni C, Feruglio PF, Courties G, Schmidt S, Hulsman M, Lee S, Wang R, Sosnovik D, Nahrendorf M, Weissleder R. System-wide characterization of cellular structures by fluorescence microscopy tensor imaging. Scientific Reports 2020, 10, 5632.

Song Y, Sun F, Redline S, Wang R. Random-effects Meta-analysis of combined outcomes based on reconstructions of individual patient data. Research Synthesis Methods 2020, forthcoming.

Wirth KE, Gaolathe T, Holme MP, Mmalane M, Kadima E, Chakalisa U, Manyake K, Mbikiwa A, Simon SV, Letlhogile R, Mukokomani K, van Widenfelt E, Moyo S, Bennett K, Leidner J, Powis K, Lebelonyane R, Alwano MG, Jarvis J, Dryden-Peterson S, Kgathi C, Moore J, Bachanas P, Raizes E, Abrams W, Block L, Sento B, Novitsky V, El-Halabi S, Marukutira T, Mills LA, Sexton C, Pals S, Shapiro R, Wang R, Lei Q, DeGruttola V, Makhema J, Essex M, Lockman S, Tchetgen Tchetgen EJ. Intervention coverage reaches UNAIDS 95-95-95 goals for treatment and viral suppression in Botswana cluster-randomized trial. Lancet HIV, forthcoming.

Tom Chen, Eric J. Tchetgen Tchetgen, Rui Wang. A stochastic second-order generalized estimating equations approach for estimating association parameters. Journal of Computational and Graphical Statistics. 2020, In press.

Liu, W., Ye, S., Barton, B., Fischer, M.A., Lawrence, C., Rahn, E.J., Danila, M.I., Saag, K.G., Harris, P.A., Lemon, S.C., Allison, J.J., Zhang, B. (2020) Simulation-based power and sample size calculation for designing interrupted time series analyses of count data outcomes in evaluation of health policy interventions. Contemporary Clinical Trials Communications, Volume 17, Pages 100474. DOI: 10.1016/j.conctc.2019.100474

Ye, S., Zhang, H., Shi, F., Guo, J., Wang, S., Zhang, B. (2020) Ensemble methods to improve prediction accuracy of suspected fetal macrosomia and large-for-gestational age. Journal of Clinical Medicine, Volume 2, Issue 9. DOI: 10.3390/jcm9020380

Wang R, Bakker JP, Chervin R,  Garetz S,  Fauziya H, Ishman SL, Mitchell R, Morrical M, Naqvi K, Rueschman M, Radcliffe J,  Riggan EI, Rosen C, Ross KR, Tapia IE, Taylor HG, Zopf DA, Redline S. Pediatric Adenotonsillectomy Trial for Snoring (PATS): Protocol for a Randomized Control Trial to Evaluate the Effect of Adenotonsillectomy in Treating Mild Obstructive Sleep-Disordered Breathing. BMJ Open 2020, Mar 15; 10(3):e033889. doi: 10.1136/bmjopen-2019-033889

Dustin J Rabideau, Rui Wang, Randomization-based confidence intervals for cluster randomized trials, Biostatistics, Caroff DA, Wang R, Zhang Z, Wolf R, Septimus E, Harris AD, Jackson SS, Polland RE, Hickok J, Huang SS, Platt R. The limited utility of ranking hospitals based on their colon surgery infection rates. Clinical Infectious Diseases 2020, Jan 9. pii: ciaa012. doi: 10.1093/cid/ciaa012. [Epub ahead of print].

Publications of 2019

Harrison LJ, Chen T, Wang R. Power calculation for cross-sectional stepped wedge cluster randomized trials with variable cluster sizes [published online ahead of print, 2019 Oct 18]. Biometrics. 2019;10.1111/biom.13164. doi:10.1111/biom.13164

Wharam JF, Zhang F, Wallace J, Lu C, Earle C, Soumerai S, Nekhlyudov L, Ross-Degnan D,  Vulnerable And Less Vulnerable Women In High-Deductible Health Plans Experienced Delayed Breast Cancer Care. Health Aff (Millwood). 2019 Mar;38(3):408-415 PMID: 30830830

Haffajee RL, Mello MM, Zhang F, Busch AB, Zaslavsky AM, Wharam JF. Association of Federal Mental Health Parity Legislation With Health Care Use and Spending Among High Utilizers of Services. Med Care. 2019 Apr;57(4):245-255. PMID: 30807450

Lewis KH, Arterburn DE, Zhang F, Callaway K, Wallace J, Fernandez A, Ross-Degnan D, Wharam JF. Comparative Effectiveness of Vertical Sleeve Gastrectomy Versus Roux en y Gastric Bypass for Diabetes Treatment: A Claims-based Cohort Study. Ann. Surg. 2019 June; PMID: 31205064

Liu, W., Haran, J.P., Ash, A.S., Allison J.J., Ye, S., Tjia, J., Bucci, V., Zhang, B. (2019) High-dimensional causal mediation analysis with a large number of mediators clumping at zero at assess the contribution of the microbiome to the risk of bacterial pathogen colonization in order adults. Current Bioinformatics, published online before print, DOI: 10.2174/1574893614666191115123219

Kang, L., Gu, H., Ye, S., Xu, B., Jing, K., Zhang, N., Zhang, B. (2019) Rural-urban disparities in caesarean section rates in minority areas in China: Evidence from electronic health records. Journal of International Medical Research, published online before print, DOI: 10.1016/j.conctc.2019.100436

Drobnyk W, Rocco K, Davidson S, Bruce S, Zhang F, Soumerai SB. Sensory Integration and Functional Reaching in Children With Rett Syndrome/Rett-Related Disorders. Clin Med Insights Pediatr. 2019 Aug; 13. PMID: 31488957.

Liu, Y., Ye, S., Xiao, X., Zhou, T., Yang, S., Wang, G., Sun, C., Zhang, B., Wang, G. (2019) Association of diabetes mellitus with hepatitis B and hepatitis C virus infection: Evidence from an epidemiology study. Infection and Drug Resistance, Volume 12, Pages 2875-2883. DOI: 10.2147/IDR.S218536

Zhang, B., Ye, S., Shankara, S.B., Zhang, H., Zheng, Q. (2019). Neutral diagnosis: An innovative concept for medical device trials. Contemporary Clinical Trials Communications, Volume 16, Pages 100436. DOI: 10.1177/0300060519877996

Madden JM, Shetty PS, Zhang F, Briesacher BA, Ross-Degnan D, Soumerai SB, Galbraith AA. Risk Factors Associated With Food Insecurity in the Medicare Population. JAMA Intern Med. 2019 Sept. PMID: 31566656.

Ye, S., Liang, Y., Ahmad, A.I. (2019). Orthogonal series density estimation for complex surveys. Journal of Nonparametric Statistics, Volume 31, Issue 2, Pages 469-481. DOI: 10.1080/10485252.2019.1585539

Petimar J, Zhang F, Cleveland LP, Simon D, Gortmaker SL, Polacsek M, Bleich SN, Rimm EB, Roberto CA, Block JP. Estimating the effect of calorie menu labeling on calories purchased in a large restaurant franchise in the southern United States: quasi-experimental study. BMJ. 2019 Oct. PMID: 31666218.

Finkelstein J, Raebel M, Nordin J, Lakoma M, Young J. Trends in outpatient antibiotic use in three health plans. Pediatrics. 2019; 143(1). pii:e20181259.

Dee EC, Hsu KK, Kruskal BA, Menchaca JT, Zambarano B, Cocoros N, Herrick B, Weiss MD, Hafter E, Erani D, Josephson M, Young J, Torrone EA, Flagg EW, Klompas M. Temporal patterns in Chlamydia Repeat Testing in Massachusetts.  American Journal of Preventive Medicine. 2019; 56(3): 458-463.

Heerman WJ, Daley MF, Boone-Heinonen J, Rifas-Shiman SL, Bailey LC, Forrest CB, Young JG, Gillman MW, Horgan CE, Janicke DM, Jenter C, Kharbanda EO, Lunsford D, Messito MJ, Toh S, Block JP; PCORnet Antibiotics and Childhood Growth Study Group. Maternal antibiotic use during pregnancy and childhood obesity at age 5 years. International Journal of Obesity (London). 2019; 43(6):1202-1209.

Derks IPM, Hivert MF, Rifas-Shiman SL, Gingras V, Young JG, Jansen PW, Oken E. Associations of prenatal exposure to impaired glucose tolerance with eating in the absence of hunger in early adolescence.  International Journal of Obesity (London). 2019; 43(10):1903-1913.

Rokoff LB, Rifas-Shiman SL, Switkowski KM, Young JG, Rosen CJ, Oken E, Fleisch AF.  Body composition and bone mineral density in childhood. Bone. 2019; 121: 9-15.

An J, Won S, Lutz SM, Hecker J, Lange C. Effect of population stratification on SNP-by-environment interaction. Genet Epidemiol. 2019 Dec;43(8):1046-1055. doi: 10.1002/gepi.22250. Epub 2019 Aug 20. PubMed PMID: 31429121; PubMed Central PMCID: PMC6829023.

Sordillo JE, Coull BA, Rifas-Shiman SL, Wu AC, Lutz SM, Hivert MF, Oken E, Gold DR. Characterization of longitudinal wheeze phenotypes from infancy to adolescence in Project Viva, a prebirth cohort study. J Allergy Clin Immunol. 2019 Nov 6;. doi: 10.1016/j.jaci.2019.10.026. [Epub ahead of print] PubMed PMID: 31705908.

Cardenas A, Lutz SM, Everson TM, Perron P, Bouchard L, Hivert MF. Mediation by Placental DNA Methylation of the Association of Prenatal Maternal Smoking and Birth Weight. Am J Epidemiol. 2019 Nov 1;188(11):1878-1886. doi: 10.1093/aje/kwz184. PubMed PMID: 31497855; PubMed Central PMCID: PMC6825837.

Cardenas A, Lutz SM, Everson TM, Hivert MF. Cardenas et al. Reply to "DNA Methylation and Prenatal Exposures". Am J Epidemiol. 2019 Nov 1;188(11):1890-1891. doi: 10.1093/aje/kwz183. PubMed PMID: 31647094.

Lowe KE, Regan EA, Anzueto A, Austin E, Austin JHM, Beaty TH, Benos PV, Benway CJ, Bhatt SP, Bleecker ER, Bodduluri S, Bon J, Boriek AM, Boueiz AR, Bowler RP, Budoff M, Casaburi R, Castaldi PJ, Charbonnier JP, Cho MH, Comellas A, Conrad D, Costa Davis C, Criner GJ, Curran-Everett D, Curtis JL, DeMeo DL, Diaz AA, Dransfield MT, Dy JG, Fawzy A, Fleming M, Flenaugh EL, Foreman MG, Fortis S, Gebrekristos H, Grant S, Grenier PA, Gu T, Gupta A, Han MK, Hanania NA, Hansel NN, Hayden LP, Hersh CP, Hobbs BD, Hoffman EA, Hogg JC, Hokanson JE, Hoth KF, Hsiao A, Humphries S, Jacobs K, Jacobson FL, Kazerooni EA, Kim V, Kim WJ, Kinney GL, Koegler H, Lutz SM, Lynch DA, MacIntye NR Jr, Make BJ, Marchetti N, Martinez FJ, Maselli DJ, Mathews AM, McCormack MC, McDonald MN, McEvoy CE, Moll M, Molye SS, Murray S, Nath H, Newell JD Jr, Occhipinti M, Paoletti M, Parekh T, Pistolesi M, Pratte KA, Putcha N, Ragland M, Reinhardt JM, Rennard SI, Rosiello RA, Ross JC, Rossiter HB, Ruczinski I, San Jose Estepar R, Sciurba FC, Sieren JC, Singh H, Soler X, Steiner RM, Strand MJ, Stringer WW, Tal-Singer R, Thomashow B, Vegas Sánchez-Ferrero G, Walsh JW, Wan ES, Washko GR, Michael Wells J, Wendt CH, Westney G, Wilson A, Wise RA, Yen A, Young K, Yun J, Silverman EK, Crapo JD. COPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2019 Nov;6(5):384-399. doi: 10.15326/jcopdf.6.5.2019.0149. PubMed PMID: 31710793.

Young KA, Regan EA, Han MK, Lutz SM, Ragland M, Castaldi PJ, Washko GR, Cho MH, Strand M, Curran-Everett D, Beaty TH, Bowler RP, Wan ES, Lynch DA, Make BJ, Silverman EK, Crapo JD, Hokanson JE, Kinney GL. Subtypes of COPD Have Unique Distributions and Differential Risk of Mortality. Chronic Obstr Pulm Dis. 2019 Nov;6(5):400-413. doi: 10.15326/jcopdf.6.5.2019.0150. PubMed PMID: 31710795.

Lutz SM, Thwing A, Fingerlin T. eQTL mapping of rare variant associations using RNA-seq data: An evaluation of approaches. PLoS One. 2019;14(10):e0223273. doi: 10.1371/journal.pone.0223273. eCollection 2019. PubMed PMID: 31581212; PubMed Central PMCID: PMC6776318.

Ragland MF, Benway CJ, Lutz SM, Bowler RP, Hecker J, Hokanson JE, Crapo JD, Castaldi PJ, DeMeo DL, Hersh CP, Hobbs BD, Lange C, Beaty TH, Cho MH, Silverman EK. Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Crit Care Med. 2019 Sep 15;200(6):677-690. doi: 10.1164/rccm.201808-1455SO. PubMed PMID: 30908940; PubMed Central PMCID: PMC6775891

Kelly RS, Sordillo JE, Lutz SM, Avila L, Soto-Quiros M, Celedón JC, McGeachie MJ, Dahlin A, Tantisira K, Huang M, Clish CB, Weiss ST, Lasky-Su J, Wu AC. Pharmacometabolomics of Bronchodilator Response in Asthma and the Role of Age-Metabolite Interactions. Metabolites. 2019 Sep 7;9(9). doi: 10.3390/metabo9090179. PubMed PMID: 31500319; PubMed Central PMCID: PMC6780678.

Chen J, Loukola A, Gillespie NA, Peterson R, Jia P, Riley B, Maes H, Dick DM, Kendler KS, Damaj MI, Miles MF, Zhao Z, Li MD, Vink JM, Minica CC, Willemsen G, Boomsma DI, Qaiser B, Madden PAF, Korhonen T, Jousilahti P, Hällfors J, Gelernter J, Kranzler HR, Sherva R, Farrer L, Maher B, Vanyukov M, Taylor M, Ware JJ, Munafò MR, Lutz SM, Hokanson JE, Gu F, Landi MT, Caporaso NE, Hancock DB, Gaddis NC, Baker TB, Bierut LJ, Johnson EO, Chenoweth M, Lerman C, Tyndale R, Kaprio J, Chen X. Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes. Nicotine Tob Res. 2019 Jul 11;. doi: 10.1093/ntr/ntz099. [Epub ahead of print] PubMed PMID: 31294817.

Lutz SM, Frederiksen B, Begum F, McDonald MN, Cho MH, Hobbs BD, Parker MM, DeMeo DL, Hersh CP, Ehringer MA, Young K, Jiang L, Foreman MG, Kinney GL, Make BJ, Lomas DA, Bakke P, Gulsvik A, Crapo JD, Silverman EK, Beaty TH, Hokanson JE. Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and Controls. Nicotine Tob Res. 2019 May 21;21(6):714-722. doi: 10.1093/ntr/nty095. PubMed PMID: 29767774; PubMed Central PMCID: PMC6528143.

Parker MM, Lutz SM, Hobbs BD, Busch R, McDonald MN, Castaldi PJ, Beaty TH, Hokanson JE, Silverman EK, Cho MH. Assessing pleiotropy and mediation in genetic loci associated with chronic obstructive pulmonary disease. Genet Epidemiol. 2019 Apr;43(3):318-329. doi: 10.1002/gepi.22192. Epub 2019 Feb 11. PubMed PMID: 30740764; PubMed Central PMCID: PMC6416067.

Liu M, Jiang Y, Wedow R, Li Y, Brazel DM, Chen F, Datta G, Davila-Velderrain J, McGuire D, Tian C, Zhan X, Choquet H, Docherty AR, Faul JD, Foerster JR, Fritsche LG, Gabrielsen ME, Gordon SD, Haessler J, Hottenga JJ, Huang H, Jang SK, Jansen PR, Ling Y, Mägi R, Matoba N, McMahon G, Mulas A, Orrù V, Palviainen T, Pandit A, Reginsson GW, Skogholt AH, Smith JA, Taylor AE, Turman C, Willemsen G, Young H, Young KA, Zajac GJM, Zhao W, Zhou W, Bjornsdottir G, Boardman JD, Boehnke M, Boomsma DI, Chen C, Cucca F, Davies GE, Eaton CB, Ehringer MA, Esko T, Fiorillo E, Gillespie NA, Gudbjartsson DF, Haller T, Harris KM, Heath AC, Hewitt JK, Hickie IB, Hokanson JE, Hopfer CJ, Hunter DJ, Iacono WG, Johnson EO, Kamatani Y, Kardia SLR, Keller MC, Kellis M, Kooperberg C, Kraft P, Krauter KS, Laakso M, Lind PA, Loukola A, Lutz SM, Madden PAF, Martin NG, McGue M, McQueen MB, Medland SE, Metspalu A, Mohlke KL, Nielsen JB, Okada Y, Peters U, Polderman TJC, Posthuma D, Reiner AP, Rice JP, Rimm E, Rose RJ, Runarsdottir V, Stallings MC, Stančáková A, Stefansson H, Thai KK, Tindle HA, Tyrfingsson T, Wall TL, Weir DR, Weisner C, Whitfield JB, Winsvold BS, Yin J, Zuccolo L, Bierut LJ, Hveem K, Lee JJ, Munafò MR, Saccone NL, Willer CJ, Cornelis MC, David SP, Hinds DA, Jorgenson E, Kaprio J, Stitzel JA, Stefansson K, Thorgeirsson TE, Abecasis G, Liu DJ, Vrieze S. Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.Nat Genet. 2019 Feb;51(2):237-244. doi: 10.1038/s41588-018-0307-5. Epub 2019 Jan 14. PubMed PMID: 30643251; PubMed Central PMCID: PMC6358542.

Young JG, Vatsa R, Murrary EJ, Hernán MA.  Interval-cohort designs and bias in the estimation of per-protocol effects: a simulation study. Trials. 2019; 20(1): 552.

Young JG, Logan RW, Robins JM and Hernán MA.  Inverse probability weighted estimation of risk under representative interventions in observational studies.  Journal of the American Statistical Association. 2019; 114(526):938-947.

Li X, Klompas M, Menchaca JT, Young JG. Effects of daily treatment with acid suppressants for stress ulcer prophylaxis on risk of ventilator-associated events.  Infection Control & Hospital Epidemiology. 2020; 41(2):187-193.

Shu D, Young JG, Toh S.  Privacy-protecting estimation of adjusted risk ratios using modified poisson regression in multi-center studies.  BMC Research Methodology. 2019 (In press).

Willis SJ, Elder H, Cocoros N, Young J, Marcus JL, Eberhardt K, Callahan M, Herrick B, Weiss M, Hafer E, Erani D, Josephson M, Llata E, Flagg EW, Hsu KK, Klompas M.  More screening or more disease? Gonorrhea testing and positivity patterns among men in three large clinical practices in Massachusetts, 2010-2017.  Clinical Infectious Diseases. 2020 (In press)

Ji W, McKenna C, Ochoa A, Ramirez Batlle H, Young J, Zhang Z, Rhee C, Clark R, Shenoy ES, Hooper D, Klompas M; CDC Prevention Epicenters Program. Development and assessment of objective surveillance definitions for nonventilator hospital-acquired pneumonia.  JAMA Network Open. 2019 (In press)

Lin PD, Daley MF, Boone-Heinonen J, Rifas-Shiman SL, Bailey LC, Forrest CB, Horgan CE, Sturtevant JL, Toh S, Young JG, Block JP. Comparing prescribing and dispensing data of the PCORnet Common Data Model within PCORnet Antibiotics and Childhood Growth Study.  eGEMs. 2019; 7(1):11.

Zhang, B., Shankara, S.B., Ye, S., Zhang, H. (2019) Design and analysis of high-risk medical device clinical trials for diabetes monitoring and treatment: A review. Journal of Pancreatology, Volume 2, Issue 4, Pages 123-130. DOI: 10.1097/JP9.0000000000000030

Liu, Y., Ye, S., Xiao, X., Sun, C., Wang, G., Wang, G. Zhang, B. (2019) Tuning, selection, and ensemble of multiple risk scores for predicting type 2 diabetes using machine learning techniques. Risk Management and Healthcare Policy, Issues 12, Pages 189-198. DOI: 10.2147/RMHP.S225762

Rhee C, Zhang Z, Kadri SS, Murphy DJ, Overton E, Schaaf R, Fram D, Seymour C, Angus D, Wang R, Klompas M, for the CDC prevention epicenters program. Sepsis surveillance using adult sepsis events simplified eSOFA criteria versus sepsis-3 sequantial organ failure assessment criteria. Critical Care medicine 2019; 47(3): 307-314. Doi: 10.1097/CCM.0000000000003521.

Kim JS, Azarbarzin A, Wang R, Djonlagic IE, Punjabi NM, Zee PC, Koo BB, Soliman EZ, Lederer DJ, Younes M, Redline S. Association of novel measures of sleep disturbances with blood pressure: The Multi-Ethnic Study of Atherosclerosis. Thorax 2019, Aug 22. Doi:10.1136/thoraxjnl-2019-213533. [Epub ahead of print]

Hsu HE, Wang R, Jentzsch MS, Horan K, Jin R, Goldmann D, Rhee C, Lee GM. The impact of measurement changes on evaluating hospital performance: The case of catheter-associated urinary tract infections. Infection Control Hospital Epidemiology 2019, 40(11):1269-1271. doi: 10.1017/ice.2019.240.

Rhee C, Wang R, Song Y, Zhang Z, Kadri SS, Fram D, Jin R, Hickok J, Roland R, Klopmas M. Risk-adjustment for sepsis mortality to facilitate hospital comparisons using Centers for Disease Control and Prevention’s adult sepsis event criteria and routine electronic clinical data. Critical Care Exploration 2019, Oct 14. doi: 10.1097/CCE.0000000000000049 

Zhao Y, Javaheri S, Wang R, Guo N, Koo BB, Stein JH, Korcarz CE, Redline S. Associations between sleep apnea and subclinical carotid atherosclerosis. Stroke 2019 Oct 15.

Harrison L, Chen T, Wang R. Power calculation for cross-sectional stepped-wedge cluster randomized trials with variable cluster sizes. Biometrics 2019 Oct 18. Doi:10.1111/biom.13164. 

Reid ML, Gleason KJ, Bakker JP, Wang R, Mittleman MA, Redline S. Effectiveness of sham-CPAP as a control intervention: Best Apnea Interventions for Research (BestAIR) Trial. Sleep 2019, 42(8). https://doi:org/10.1093/sleep/zsz099.

Rhee C, Wang R, Zhang Z, Kadri SS, Fram D, Jin R, Klompas M. Epidemiology of hospital-onset sepsis in US hospitals and association with mortality: A retrospective analysis using electronic clinical data. Critical Care Medicine 2019, 47(9): 1169-1176. doi: 10.1097/CCM.0000000000003817.  

Makhema J, Wirth K, Holme MP, Gaolathe T, Mmalane M, Kadima E, Chakalisa U, Manyake K. Mbikiwa A, Simon SV, Letlhogile R, Mukokomani K, van Widenfelt E, Moyo S, Bennett K, Leidner J, Lebelonyane R, Alwano MG, Powis K, Dryden-Peterson S, Kgathi C, Novitsky V, Moore J, Bachanas P, Abrams W, Block L, El-Halabi S, Murukutira T, Mills LA, Sexton C, Bussmann H, Okui L, John O, Sahpiro R, Michael H, Roland M, DeGruttola V, Lei Q, Wang R, Tchetgen Tchetgen E, Essex M, Lockman S. Universal test and treat strategy reduces population HIV incidence. NEJM 2019, 381:230-42

Kahn R, Hitchings M, Wang R, Bellan S and Lipsitch M. Modeling vaccine trials in epidemics with mild and asymptomatic infection.  American Journal of Epidemiology 2019; 188(2), 467-474.  

Rhee C, Wang R, Jentzsch MS, Broadwell C, Hsu H, Jin R, Horan K, Lee GM. Comparison of hospital surgical site infection rates and rankings using claims versus national healthcare safety network surveillance data.  Infection Control & Hospital Epidemiology 2019; 40(2): 208-210.

Xu Y, Laeyendecker O, Wang R. Cross-sectional HIV incidence estimation accounting for heterogeneity across communities. Biometrics 2019, 75(3):1017-1028. 

Hsu HE, Wang R, Jentzsch MS, Horan K, Jin R, Rhee C, Lee GM. Association between value-based incentive programs and catheter-associated urinary tract infection rates in the critical care setting. JAMA 2019; 321(5): 509-511. 

Rhee C, Jentzsch MS, Kadri SS, Seymour CW, Angus DC, Murphy DJ, Martin GS, Dantes R, Epstein L, Fiore A, Jernigan JA, Septimus E, Danner RL, Warren DK, Iwashyna TJ, Jin R, Fram D, Schaaf R, Wang R, and Klompas M, for the CDC Prevention Epicenters Program. Variation in identifying sepsis and organ dysfunction using administrative versus electronic clinical data and impact on hospital outcome comparisons. Critical Care Medicine 2019; 47(4):493-500. Doi: 10.1097/CCM.0000000000003554

Publications of 2018

Moyo S, Gaseitsiwe S, Mohammed T, Holme MP, Wang R, Kotokwe KP, Boleo C, Mupfumi L, Yankinda EK, Chakalisa U, van Widenfelt E, Gaolathe T, Mmalane M, Dryden-Peterson S, Mine M, Lebelonyane R, Bennett K, Leidner J, Wirth KE, Tchegen Tchetgen E, Powis K, Moore J, Lockman S, Makhema JM, Essex M, and Novitsky V. Cross-sectional estimates revealed high HIV incidence in Botswana rural communities in the era of successful ART scale-up in 2013-2015. PloS one, 13(10), e0204840.

Quante M, Mariani S, Weng J, Marinac CR, Kaplan ER, Rueschman M, Mitchell JA, James P, Hipp JA, Feliciano EMC, Wang R, Redline S. Zeitgebers and their association with rest-activity patterns. Chronobiology International, 2018; 1-11.

Rhee C, Wang R, Jentzsch MS, Hsu H, Kawai AT, Jin R, Horan K, Carly Broadwell, Lee GR. Impact of the 2012 Medicaid healthcare-acquired conditions policy on catheter-associated urinary tract infection and vascular catheter associated infection billing rates. Open Forum Infectious Disease 2018, 5(9): ofy204.     

Petrov ME, Weng J, Reid KJ, Wang R, Ramos AR, Wallace DM, Alcantara C, Cai J, Perreira K, Giacinto RA, Zee PC, Sotres-Alvarez D, Patel SR. Commuting and sleep: Results from the HCHS/SOL Sueno ancillary study. American Journal of Preventive Medicine 2018; 54(3), e49-e57.

Meyers DJ, Chien A, Nguyen KH, Li Z, Singer S, Rosenthal MB. Association of Team-Based Primary Care With Health Care Utilization and Costs Among Chronically Ill Patients JAMA Internal Medicine 2018 Nov.

Quante M, Kaplan ER, Cailler M, Rueschman M, Wang R, Weng J, Taveras EM, Redline S. Actigraphy-based sleep estimation in adolescents and adults: A comparison with polysomnography using two scoring algorithms. Nature and Science of Sleep 2018; volume 2018:10, 13-20.

Glaucylara G, Wang R, Weng J, Tracy R, Jenny N, Goldberger A, Costa M, Liu Y, Libby P, Redline S. Elevations in neutrophils with obstructive sleep apnea: the Multi-Ethnic Study of Atherosclerosis (MESA). International Journal of Cardiology 2018; 257:318-32

Hitchings M, Lipsitch M, Wang R, Bellan S. Competing effects of indirect protection and clustering on the power of cluster-randomized controlled vaccine trials. American Journal of Epidemiology 2018; 1763–1771

Hsu H, Kawai AT, Wang R, Jentzsch MS, Rhee C, Horan K, Jin R, Goldmann D, Lee GM. The impact of the Medicaid health care-associated condition program on mediastinitis following coronary artery bypass graft. Infection Control & Hospital Epidemiology 2018; 39(6): 694-700.  

Glaucylara G, Wang R, Weng J, Nancy J, Steven S, Matthew A, Libby P, Redline S. Association between obstructive sleep apnea and cardiovascular risk factors – variation by age, sex, and race: the Multi-Ethnic Study of Atherosclerosis (MESA). The Annals of the American Thoracic Society 2018; 15(8):970-977

Rhee C, Massaro A, Bulger A, McEachern D, Filbin M, Tobin K, Kitch B, Thurlo-Walsh B, Kadar A, Koffman A, Pande A, Hamad Y, Warren D, Jones T, Anderson D, Wang R, Klompas M for the CDC Prevention Epicenters Program. Compliance with the national SEP-1 Quality Measure and Association with Sepsis Outcomes: A multicenter retrospective cohort study. Critical Care Medicine 2018, Volume Online First - issue – p

Johnson DA, Guo N, Rueschman M, Wang R, Wilson JG, Redline S. Prevalence and correlates of obstructive sleep apnea among African Americans: the Jackson Heart Sleep Study. Sleep 2018,195:A2926

Isaac T, Rosenthal MB, Colla CH, Morden NE, Mainor AJ, Li Z, Nguyen KH, Kinsella EA, Sequist TD. Measuring Overuse with Electronic Health Records Data. Am J Manag Care. 2018;24(1):19-25.

Cohen JFW, Rifas-Shiman SL, Young J, Oken E. Associations of prenatal and child sugar intake with child cognition. American Journal of Preventive Medicine. 2018: 727–735

Her QL,, Malenfant JM, Malek S, Vilk Y, Young J, Li L, Brown B, and Toh S. A query workflow design to perform automatable distributed regression analysis in large distributed data networks. eGEMs. 2018. 6(1):11

Jiang Y, Chen S, McGuireD, Chen F, Liu M, Iacono WG, Hewitt JK, Hokanson JE, Krauter K, Laakso M, Li KW, Lutz SM, McGue M, Pandit A, Zajac G, Boehnke M, Abecasis GR, Vrieze SI, Zhan X, Jiang B, Liu DJ. (2018) Proper Conditional Analysis in the Presence of Missing Data: Application to Large Scale Meta-analysis of Tobacco Use Phenotypes. Plos Genetics. (In Press).

Kinney GL, Santorico S, Young K, Cho M, Castaldi P, San Jose Estapar R, Ross J, Dy J, Make B, Regan E, Lynch D, Everett DC, Lutz SM, Silverman EK, Washko G, Crapo J, Hokanson JE, and the COPDGene Investigators. (2018) Identification of Chronic Obstructive Pulmonary Disease Axes That Predict All-Cause Mortality: The COPDGene Study. American Journal of Epidemiology. (In Press)

Glasheen C, Johnson EO, Saccone NL, Lutz SM, Baker TB, McNeil DW, Marazita ML, Hokanson JE, Bierut LJ, Hancock DB (2018) Is the Fagerström Test for Nicotine Dependence Invariant across Secular Trends in Smoking? A Question for Cross-Birth Cohort Analysis of Nicotine Dependence. Drug and Alchol Dependence. (185):127-132.

Bhatt SP, Kim YI, Harrington KF, Hokanson JE, Lutz SM, Cho MH, Demeo DL, Wells JM, Make BJ, Rennard SI, Washko GR, Foreman MG, Tashkin DP, Wise RA, Dransfield MT, Bailey WC, and the COPDGene Investigators. (2018) Smoking duration alone provides stronger risk estimates of chronic obstructive pulmonary disease than pack-years. Thorax. 73(5): 414-421.

Publications of 2017 

Harling G, Wang R, Onnela JP, De Gruttola V. Leveraging contact network structure in the design of cluster randomized trials. Clinical Trials 2017; 14(1): 37-47. 

Zhao YY, Weng J, Mobley DR, Wang R, Kwon Y, Zee PC, Lutsey PL, Redline S. Effect of manual editing of total recording time – implications for home sleep testing. Journal of Clinical Sleep Medicine 2017 13(1): 121-126.

Wang R, Dong Y, Weng J, Kontos EZ, Chervin RD, Rosen CL, Marcus CL, Redline S. Associations among neighborhood, race and sleep apnea severity in children: a six city analysis. Annals of the American Thoracic Society 2017; 14(1):76-84.

Dudley KA, Weng J, Sotres-Alvarez D, Simoneli G, Cespedes E, Ramirez M, Ramos AR, Loredo JS, Reid KJ, Mossavar-Rahmani Y, Zee PC, Chirinos DA, Gallo LC, Wang R, Patel SR.Actigraphic sleep patterns ofU.S. Hispanics: Results from the Hispanic Community Health Study/Study of Latinos ancillary Sueño study. Sleep 2017; 40(2).

Kassanjee R, De Angelis D, Farah M, Hanson D, Labuschagne P, Laeyendecker O, Le Vu S, Tom B, Wang R, Welte A. Cross-sectional HIV incidence surveillance: A benchmarking of approaches for estimating the ‘Mean Duration of Recent Infection’. Statistics Communications in Infectious Diseases; published online March 14, 2017.

Moyo S, Wilkinson E, Vandormael A, Wang R, Weng J, Kotokwe KP, Gaseitsiwe S, Mudonda R, Essex M, Engelbrecht S, de Oliveira T, Novitsky V. Pairwise diversity and tMRCA as potential markers for HIV infection recency. Medicine 2017; 96(6):e6041. doi: 10.1097/MD.0000000000006041.

Yasmin M, Weng J, Wang R, Shaw PA, Jung M, Sotres-Alvarez D, Castaneda SF, Gallo LC, Gellman MD, Qi Q, Ramos AR, Reid KJ, Horn LV, Patel SR. Actigraphic sleep measures and diet quality in the Hispanic Community Health Study/Study of Latinos Sueno ancillary study. Journal of Sleep Research 2017; March 27, Epub ahead of print.

Zhao YY, Wang R, Lewis EF, Gleason KJ, Quan SF, Toth CM, Morrical M, Rueschman M, Weng J, Ware JH, Mittleman MA, Redline S, for the BestAIR Investigators. Effect of continuous positive airway pressure treatment on health-related quality of life and sleepiness in high cardiovascular risk individuals with sleep apnea: Best Apnea Interventions for Research (BestAIR) Trial. Sleep 2017; 40(4), p.zsx040.

Huvane J, Komarow L, Hill C, Tran TT, Pereira C, Rosenkranz SL, Finnemeyer M, Earley M, Jiang H, Wang R, Lok J, Evans SR, for the Statistical and Data Management Center of the Antibacterial Resistance Leadership Group (ARLG); Fundamentals and Catalytic Innovation: The Statistical and Data Management Center of the Antibacterial Resistance Leadership Group. Clin Infect Dis 2017; 64 (suppl_1): S18-S doi: 10.1093/cid/ciw827

Wang R, DeGruttola V. The use of permutation tests for the analysis of parallel and stepped-wedge cluster-randomized trials. Statistics in Medicine 2017, Epub ahead of print May 2, 2017. doi: 1002/sim.7329.

Waksman R, Torguson R, Spad M, Garcia-Garcia H, Ware J, Wang R, Madden S, Shah P, Muller J. The lipid-rich plaque study of vulnerable plaques and vulnerable patients: study design and rationale. American Heart Journal 2017, 192: 98-104.

Lewis EF, Wang R, Punjabi N, Gottlieb DJ, Quan SF, Bhatt DL, Patel SR, Mehra R, Blumenthal RS, Weng J, Rueschman M, Redline S. Impact of continuous positive airway pressure and oxygen on health status in patients with coronary heart disease, cardiovascular risk factors, and obstructive sleep apnea: a HEARTBEAT analysis. American Heart Journal2017, 189: 59-67.

Yang KS, Im H, Hong S, Pergolini I, del Castillio AF, Wang R, Clardy S, Huang C, Pille C, Ferrone S, Yang R, Castro C, Lee H, del Castillo CF, Weissleder R. Multi-parametric plasma EV profiling facilitates diagnosis of pancreatic malignancy. Science Translational Medicine2017; May 24: 9(391), eaal3226.

Tung P, Levitzky YS, Wang R, Weng J, Quan SF, Gottlieb DJ, Rueschman M, Punjabi NM, Mehra R, Bertisch S, Benjamin EJ, Redline S. Obstructive and central sleep apnea and the risk of incident atrial fibrillation in a community cohort of men and women. Journal of the American Heart Association 2017, 6(7), pii:e004500.  

Mitchell JA, Quante M, Godbole S, James P, Hipp JA, Marinac CR, Mariani S, Cespedes Feliciano EM, Glanz K, Laden F, Wang R, Weng J, Redline S, Kerr J. Variation in actigraphy-estimated rest-activity patterns by demographic factors. Chronobiology International 2017, 34(8): 1042-1056.

Johnson DA, Lane J, Wang R, Reid M, Djonlagic I, Fitzpatrick AL, Rapp SR, Charles LE, O’Hara R, Saxena R, Redline S. Greater cognitive deficits with sleep-disordered breathing among individuals with genetic susceptibility to Alzheimer’s disease: the multi-ethnic study of Atherosclerosis. Annals of the American Thoracic Society 2017; 14(11):1697-1705.

Prague M, Wang R, De Gruttola V. CRTgeeDR: an R package for doubly robust generalized estimating equations estimations in cluster-randomized trials with missing data. The R Journal 2017; accepted for publication.

Quante M, Wang R, Weng J, Kaplan ER, Rueschman M, Taveras EL, Rifas-Shiman SL, Gillman MW, Redline S. Seasonal and weather variation of sleep and physical activity in 12-14-year old children. Behavioral Sleep Medicine 2017; accepted for publication.

Rhee C, Dantes R, Epstein L, Murphy DJ, Seymour CW, Iwashyna TJ, Kadri SS, Angus DC, Danner RL, Fiore A, Jernigan JA, Magill SS, Marin GS, Septimus E, Warren DK, Karcz A, Chan C, Menchaca JT, Wang R, Gruber S, Klompas M, for the CDC Prevention Epicenters Program. Estimating the burden of sepsis in the United States using clinical data. JAMA2017; 318(13): 1241-1249.

Donovan L, Rueschman M, Weng J, Basu N, Dudley K, Bakker J, Wang R, Bertisch S, Patel S. The effectiveness of an obstructive sleep apnea screening and treatment program in patients with type 2 diabetes. Diabetes Research and Clinical Practice 2017; 134: 145-152. 

Colla CH., Morden NE., Sequist TD, Mainor AJ., Li Z., Rosenthal MB. Payer Type and Low-Value Care: Comparing Choosing Wisely Services Across Commerical and Medicare Populations.  Health Serv Res. 2017 Feb.

Wachterman M., ,Lipsitz S., Lorenz K., Marcantonio E., Li Z., Keating N.  End-of-Life Experience of Older Adults Dying of End-Stage Renal Disease: A Comparison With Cancer. J Pain Sympton Manage. 2017 Aug 24.

Plough A., Galvin G., Li Z., Lipsitz S., Alidina S., Henrich N., Hirschhorn L., Berry W., Gawande A., Peter D., McDonald R., Caldwell D., Muri J., Bingham D., Caughey A., Declercq E., and Shah N.  Relationship Between Labor and Delivery Unit Management Practices and Maternal Outcomes. Obstetrics and Gynecology. Aug 2017.

Bleich SN., Vercammen KA., and Li Z. Trends in Beverage Consumption Among Children and Adults, 1999-2014.  Obesity (Silver Spring). 2017 Nov 14.

Molina G, Berry WR, Lipsitz S, Edmondson L, Li Z., N BA, Moonan AT, Gibbons L, Singer SJ, Haynes AB. Perception of Safety of Surgical Practice among Operating Room Personnel from Survey Data is Asscoiated with All-cause 30-day Postoperative Death Rate in South Carolina.  Annals of Surgery: June 2017.

Lin S, Young J, Logan R, Tchetgen Tchetgen EJ, Vanderweele TJ. Parametric mediational g-formula approach to mediation analysis with time-varying exposures, mediators and confounders.  Epidemiology. 2017;28(2):266-274.

Zhang Y, Young JG, Thamer M, Hernán MA. Comparing the effectiveness of dynamic treatment strategies using electronic health records: an application of the parametric g-formula to anemia management strategies. Health Services Research.  2017 (In press). 

Lin S, Young J, Logan R, Vanderweele TJ. Mediation analysis for a survival outcome with time-varying exposures, mediators, and confounders. Statistics in Medicine. 2017;36(26):4153-4166.

Cocoros NM, Priebe G, Gray JE, Toltzis P, Larsen GY, Logan LK, Coffin S, Sammons JS, Deakins K, Horan K, Lakoma M, Young J, Burton M, Klompas M, Lee GM. Factors Associated With Pediatric Ventilator-Associated Conditions in Six U.S. Hospitals: A Nested Case-Control Study. Pediatric Critical Care Medicine. 2017; 18(11):e536-e545.

Li LJ, Rifas-Shiman S, Aris I, Young J, Mantzoros C, Hivert MF, Oken E. Associations of Maternal and Cord Blood Adipokines with Offspring Adiposity in Project Viva: Is There An Interaction with Child Age? International Journal of Obesity. 2017 (In press)

Li X, Young JG, Toh S.  Estimating effects of dynamic treatment strategies in pharmacoepidemiologic studies with time-varying confounding: a primer. Current Epidemiology Reports. 2017;4(4): 288-297. McDonald MLN, Diaz AA, Rutten E, Lutz SM, Harmouche R, San Jose Estepar R, Kinney G, Hokanson J, Gower BA, Wouters EFM, Rennard SI, Hersh CP, Casaburi R, Dransfield M, Silverman EK, Washko GR. (2017) Chest CT Derived Low Fat-Free Mass Index and Mortality in COPD. European Respiratory Journal. 50(6).

Lutz SM, Thwing A, Schmiege S, Kroehl M, Baker C, Starling A, Hokanon JE, Ghosh D. (2017) Examining the Role of Unmeasured Confounding in Mediation Analysis with Genetic and Genomic Applications. BMC Bioinformatics. 18(1):344.

Melroy-Greif WE, Simonson MA, Corley RP, Lutz SM, Hokanson JE, Ehringer MA. (2017) Examination of the Involvement of Cholinergic-Associated Genes in Nicotine Behaviors in European and African Americans. Nicotine and Tobacco Research. 19(4):417-425.

Boueiz A, Lutz S, Cho MH, Hersh C, Bowler R, Washko G, Halper-Stromberg E, Bakke P;Gulsvik A, Laird N, Beaty T, Coxson H, Crapo J, Silverman EK, Castaldi P, DeMeo DL. (2017) Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. Amer J Resp Crit Care Med. 195(6):757-771.

Hartz SM, Caporaso NE, Chen LS, Hancock D, Horton A, Lutz SM, Hokanson JE, Johnson EO, Pato C, Pato M, Bierut LJ. (2017) Genetic Correlation Between Smoking Behaviors and Schizophrenia. Schizophrenia Research. S0920-9964 (17) 30111-1.

Qiao D, Lange C, Laird NM, Won S, Hersh CP, Morrow J, Hobbs B, Lutz SM, Ruczinski I, Crapo JD, Beaty TH, Silverman EK, Cho MH. (2017) Gene-based Segregation Method for Identifying Rare Variants in Family-based Sequencing Studies. Genetic Epidemiology. . 41(4): 309-319

Publications of 2016

Chen X, Wang R, Lutsey PL, Zee PC, Javaheri S, Alcantara C, Jackson CL, Szklo M, Punjabi N, Redline S and Williams MA. Racial/Ethnic differences in the associations between obesity measures and severity of sleep-disordered breathing: the multi-ethnic study of atherosclerosis. Sleep Medicine 2016, 26: 46-53. 

Cespedes EM, Hu FB, Redline S, Rosner B, Alcantara C, Cai J, Hall M, Mossavar-Rahmani Y, Ramos AR, Reid KJ, Shah NA, Sotres-Alvarez D, Zee PC, Wang R, Patel SR. Validation and calibration of self-reported sleep duration against actigraphy: results from Sueno and the Hispanic Community Health Study/Study of Latinos. American Journal of Epidemiology, 2016; 183(6):561-73.

Javaheri S, Sharma R, Wang R, Weng J, Rosen BD, Bluemke DA, Lima JA, Redline S. Association between obstructive sleep apnea and left ventricular structure by age and gender: the multiethnic study of atherosclerosis.   Sleep, 2016; 39(3):523-9. 

Farahani M, Novitsky V, Wang R, Bussmann H, Moyo S, Musonda R, Moeti T, Makhema JM, Essex M and Marlink R. Prognostic value of HIV-1 RNA on CD4 trajectories and disease progression among antiretroviral-naïve HIV-infected adults in Botswana: a joint modeling analysis. AIDS Research and Human Retroviruses, 2016; 32(6):573-8.

Prague M, Wang R, Alisa Stephens, Tchetgen Tchetgen E, DeGruttola V. Accounting for interactions and complex inter-subject dependency in estimating treatment effect in cluster randomized trials with missing outcomes. Biometrics 2016; 72(4): 1066-1077.

Bakker J, Wang R, Weng J, Aloia M, Toth C, Morrical M, Gleason K, Rueschman M, Dorsey C, Patel S, Ware J, Mittleman M, Redline S. Motivational enhancement for increasing adherence to CPAP: A randomized controlled trial. Chest 2016, 150(2): 337-45.  

Gaolathe T, Wirth KE, Holme MP, Makhema J, Moyo S, Chakalisa U, Yankinda EK, Lei Q, Mmalane M, Novitsky V, Okui L, van Widenfelt E, Powis KM, Khan N, Bennett K, Bussmann H, Dryden-Peterson S, Lebelonyane R, el-Halabi S, Mills LA, Marukutira T,Wang R, Tchetgen Tchetgen EJ, DeGruttola V, Essex M, Lockman S, and the BCPP study team. Botswana close to achieving the ambitious 2020 UNAIDS goals for population-level antiretroviral treatment and virologic suppression. Lancet HIV 2016; 3(5):e221-30.  

Carnegie NB, Wang R, De Gruttola V. Estimation of the overall treatment effect in the presence of interference in cluster-randomized trials of infectious disease prevention. Epidemiologic Methods 2016; 5(1), 57-6

Simonelli G, Dudley KA, Weng J, Gallo LC, Perreira K, Shah NA, Alcantara C, Zee PC, Ramos AR, Llabre MM, Sotres-Alvarez D, Wang R, Patel SR. Neighborhood factors as predictors of poor sleep in the Sueno ancillary study of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Sleep 2016; Sep 26. pii: sp-00392-16

Novitsky V, Moyo S, Wang R, Gaseitsiwe S, Essex M. Deciphering multiplicity of HIV-1C infection: Transmission of closely related multiple viral lineages. PLoS ONE 2016; 11(11): e0166746. doi:1371/journal.pone.0166746.

Singer SJ, Molina G, Li Z., Berry WR.  Relationship between Operating Room Teamwork, Contextual Factors, and Saftey Checklist Performance.  Journal of the American College of Surgeons. July 2016.

Danaei G, Robins JM, Young JG, Hu FB, Manson JE, and Hernán MA.  Weight loss and coronary heart disease: sensitivity analysis for unmeasured confounding by undiagnosed disease. Epidemiology. 2016;27(2):302-10.

Begum F, Ruczinski I, Hokanson JE, Lutz SM, Parker MM, Cho MH, Hetmanski JB, Scharpf RB, Crapo J, Silverman EK, Beaty TH. (2016) Hemizygous Deletion on Chromosome 3p26.1 is Associated with Heavy Smoking Among African American Subjects in the COPDGene Study. PLOS ONE. 11(10).

Publications of 2015

Dean D, Wang R, Jacobs D, Duprez D, Punjabi NM, Zee P, Shea SJ, Watson K, Redline S. A systematic assessment of the association of polysomnographic indices with blood pressure: the Multi-Ethnic Study of Atherosclerosis (MESA). Sleep, 2015; 38(4):587-596.

Chen X, Wang R, Zee P, Lutsey PL, Javaheri S, Alcantara C, Jackson CL, Williams MA, Redline S. Racial/ethnic differences in sleep disturbances: the Multi-Ethnic Study of Atherosclerosis (MESA). Sleep, 2015; 38(6):877-888.

Rosen CL, Wang R, Taylor HG, Marcus CL, Katz ES, Paruthi S, Arens R, Muzumdar H, Garetz SL, Mitchell RB, Jones D, Weng J, Ellenberg S, Redline S, Chervin RD. Utility of symptoms to predict treatment outcomes in obstructive sleep apnea syndrome. Pediatrics, 2015; 135(3).

Quante M, Wang R, Weng J, Rosen CL, Amin R, Garetz S, Katz E, Paruthi S, Arens R, Muzumdar H, Marcus CL, Ellenberg S, Redline S; and for the Childhood Adenotonsillectomy Trial (CHAT). The impact of adenotonsilletomy for childhood sleep apnea on cardiometabolic measures. Sleep, 2015; 38(9):1395-403.

Wang R, Schoenfeld DA, Hoeppner B, Evins AE. Detecting treatment-covariate interactions using permutation methods. Statistics in Medicine, 2015; 34(12): 2035-2047.

Patel SR, Weng J, Rueschman M, Dudley K, Loredo JS, Mossavar-Rahmani Y, Ramos AR, Reid K, Sotres-Alvarez D, Zee PC, Wang R. Assessing the reproducibility of a standardized actigraphy scoring algorithm in a Hispanic/Latino population. Sleep, 2015; 38(9):1497-503. 

Bakker JP, Weng J, Wang R, Redline S, Punjabi NM, Patel SR. Associations between obstructive sleep apnea, sleep duration, and abnormal fasting glucose: The Multi-Ethnic Study of atherosclerosis. American Journal of Respiratory and Critical Care Medicine, 2015, 192(6):745-53.

Paruthi S, Rosen CL, Wang R, Weng J, Marcus CL, Chervin RD, Stanley JJ, Katz E, Amin R, Redline S. Capnography: signal quality and association with pediatric obstructive sleep apnea severity.  Sleep, 2015, 38(11):1719-1726.

Goyal R, Wang R, DeGruttola V. Network Epidemic Modeling: Assumptions and Interpretations. Clinical Infectious Disease 2012; 55(2): 276-8.

Rosenthal MB,., Friedberg M, Singer SJ, Eastman D, Li Z., Schneider E. Impact of the Colorado Multi-Payer Patient-Centered Medical Home Pilot on Health Care Quality, Utilization and Cost.  Journal of General Internal Medicine 31(3); Octoboer 2015.

Rosenthal MB,., Friedberg M, Singer SJ, Eastman D, Li Z., Schneider E. Impact of the Cincinnati Aligning Forces for Quality Multi-Payer Patient Centered Medical Home pilot on Healthcare Quality, Utilization, and Costs. Medical Care Research and Review. Nov 2015

Zhou JJ, Cho MH, Lange C, Lutz S, Silverman EK, Laird NM. (2015) Integrating Multiple Correlated Phenotypes for Genetic Association Analysis by Maximizing Heritability. Human Heredity. 79(2): 93-104.

Pre-2015 Publications

Young JG, Eskenazi B, Gladstone EA, Bradman A, Pedersen L, Johnson C, Barr DB, Furlong CE, and Holland NT.  Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates.  Neurotoxicology.  2005;26(2):199-209.

Eskenazi B, Warner M, Samuels S, Young J, Gerthoux P, Needham L, Patterson D, Castorina R, Olive D, Gavoni N,  Vercellini P, and Mocarelli P. Serum dioxin concentrations and risk of uterine fibroids in the Seveso Women's Health Study. American Journal of Epidemiology. 2007;166(1):79-87.

Young JG, Jewell NP, and Samuels S. Regression analysis of a disease onset distribution using diagnosis data. Biometrics. 2008;64(1):20-8. PMCID: PMC2453193

Young JG, Hernán MA, Picciotto S, and Robins JM. Relation between three classes of structural models for the effect of a time-varying exposure on survival. Lifetime Data Analysis. 2010;16(1):71-8  PMCID: PMC3635680

Young JG, Cain LE, Robins JM, O'Reilly EJ, and Hernán MA. Comparative effectiveness of dynamic treatment regimes: an application of the parametric g-formula. Statistics in Biosciences. 2011;3(1):119-43.  PMCID: PMC3769803

Picciotto S, Hernán MA, Page JH, Young JG, and Robins JM. Structural nested cumulative failure time models to estimate the effects of interventions. Journal of the American Statistical Association. 2012;107(499):886-900.  PMCID: PMC3860902

Westreich D, Cole SR, Young JG, Palella F, Tien PC, Kingsley L, Gange SJ, and Hernán MA. The parametric g-formula to estimate the effect of highly active antiretroviral therapy on incident AIDS or death. Statistics in Medicine. 2012;31(18):2000-9.  PMCID: PMC3641816

Lajous M, Willett WC, Robins JM, Young JG, Rimm E, Mozaffarian D, and Hernán MA. Changes in fish consumption in midlife and the risk of coronary heart disease in men and women. American Journal of Epidemiology. 2013;178(3):382-91.  PMCID: PMC3727335

Young JG and Tchetgen Tchetgen EJ.  Simulation from a known Cox MSM using standard parametric models for the g-formula. Statistics in Medicine. 2014; 33(6):1001-14.  PMCID: PMC3947915

Young JG, Hernán MA, and Robins JM.  Identification, estimation and approximation of risk under interventions that depend on the natural value of treatment using observational data. Epidemiologic Methods. 2014; 3(1): 1-19.  PMCID: PMC4387917

Jacobson J, Lederman M, Spritzler J, Valdez H, Tebas P, Skowron G,  Wang R, Jackson JB, Fox L, and Gilbert M, for the ACTG 5041 Team. Granulocyte-Macrophage Colony-Stimulating Factor induces modest increases in plasma HIV RNA and CD4 lymphocyte counts in patients with uncontrolled HIV infection. The Journal of Infectious Diseases 2003; 188:1804-1814.

Malhotra U, Bosch RJ, Chan E, Wang R, Fischl MA, Collier AC, and McElrath JM.  Association of T cell proliferative responses and phenotype with virus control in chronic progressive HIV-1 disease.  The Journal of Infectious Disease 2004; 189:515-5

Malhotra U, Bosch RJ, Wang R, Collier A, McElrath MJ. Effect of adjunct Hydroxyurea on helper T cell immunity in HIV-1-Infected patients with virologic suppression. AIDS Research and Human Retroviruses 2004; 20: 807-12.

Jacobson JM, Bucy PR, Spritzler J, Saag MS, Eron J, Coombs RW, Wang R, Fox L, Johnson VA, Cu-Uvin S,  Cohn S, Mildvan D, O’Neil D, Janik J, Purdue L, O’Connor DK, Vita CD, Frank I and the NIAID -- ACTG 5068 Protocol Team.   Evidence that intermittent structured treatment interruption (STI), but not immunization with ALVAC-HIV vCP1452, promotes host control of HIV replication: the results of AIDS Clinical Trials Group 5068.  The Journal of Infectious Diseases 2006; 194: 623-32.

Benson CA, Vaida F, Havlir DV, Downey GF, Lederman MM, Gulick RM, Glesby MJ, Wantman M, Bixby CJ, Rinehart AR, Snyder S, Wang R, Patel S,  and Mellors JW, the ACTG A5086 Study Team. A randomized trial of treatment interruption followed by optimized antiretroviral therapy for persons with drug resistant HIV: 48-week virologic results of ACTG A5086. The Journal of Infectious Diseases 2006; 194: 1309-18.

Bosch RJ, Wang R, Vaida F, Lederman MM, Albrecht MA, and the AIDS Clinical Trial Group 364 Study Team. Changes in the slope of the CD4 cell count increase after initiation of potent antiretroviral treatment. The Journal of Acquired Immune Deficiency Syndromes (JAIDS) 2006; 43: 433-5.

Evans SR, Wang R, Yeh T, Anderson J, Haija R, Mcbratney-Owen PM, Peeples L, Sinha S, Xanthakis V, Rajicic N, Zhang J. Evaluation of distance learning in an `Introduction to Biostatistics' class: a case study. Statistical Education Research Journal 2007; 6(2): 59-77.

Wang R, Lagakos SW, Ware JH, Hunter DJ, Drazen JM. Statistics in medicine - reporting of subgroup analyses in clinical trials. New England Journal of Medicine 2007; 357:2189-94. [Also included in: Medical Use of Statistics, Bailar JC and Hoaglin DC ed., Wiley , 343-352, 2009.]

Novitsky V, Wang R, Kebaabetswe L, Greenwald J, Rossenkhan R, Moyo S, Musonda R, Woldegabriel E, Lagakos SW, and Essex M.  Better control of early viral replication is associated with slower rate of elicited antiviral antibodies in the detuned EIA during primary HIV-1C infection. The Journal of Acquired Immune Deficiency Syndromes (JAIDS) 2009; 52: 265-272.

Souglakos J, Philips J, Wang R, Marwah S, Silver M, Tzardi M, Silver J, Ogino S, Hooshmand S, Kwak E, Freed E, Meyerhardt JA, Saridaki Z, Georgoulias V, Finkelstein D, Fuchs CS, Kulke MH, and Shivdasani RA. Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. British Journal of Cancer 2009; 101,465-472.

Wang R, Lagakos SW. Inference after variable selection using restricted permutation methods. Canadian Journal of Statistics, 2009; 37(4), 625-644.

Wang R, Lagakos SW. On the use of adjusted cross-sectional estimators of HIV incidence. The Journal of Acquired Immune Deficiency Syndromes (JAIDS), 2009; 52(5):538-47.

Novitsky V, Wang R, Margolin L, Baca J, Kebaabetswe L, Rossenkhan R, Bonney C, Herzig M, Nkwe D, Moyo S, Musonda R,  Woldegabriel E, van Widenfelt E, Makhema J, Lagakos S, and Essex M. Timing constraints of in Vivo gag mutations during primary HIV-1 subtype C infection. PLoS One. 2009 Nov 5; 4(11):e7727.

Wang R, Tian L, Cai T, Wei LJ. Nonparametric inference procedure for percentiles of the random effects distribution in meta analysis. The Annals of Applied Statistics, 2010; 4(1): 520-532.

Novitsky V, Wang R, Lagakos S, and Essex M. HIV-1 subtype C phylodynamics in the global epidemic. Viruses 2010; 2(1):33-54.

Rothenberg SM, Mohapatra G, Rivera MN, Winokur D, Nitta M, Sadow PM, Sooriyakumar G, Brannigan BW, Ulman MJ, Perera RM, Wang R, Ma X, Erlander M, Rocco JW, Cohen E, Louis DN, Settleman J, Haber DA. A genome-wide screen for microdeletions reveals disruption of polarity gene components in diverse human cancers. Cancer Research, 2010; 70(6): 2158-64.

Novitsky V, Wang R, Bussmann H, Lockman S, Baum M, Shapiro R, Thior I, Wester C, Wester CW, Ogwu A, Asmelash A, Musonda R, Moyo S, van Widenfelt E, Mine M, Moffat C, Mmalane M, Makhema J, Marlink R, Gilbert P, Seage GR, De Gruttola V, and Essex M. HIV-1 subtype C infected individuals maintaining high viral load as a potential target for the “Test-and-Treat” approach to reduce HIV transmission. PLoS One, 2010; 5(4): e10148.

Novitsky V, Wang R, Margolin L, Baca J, Moyo S, Musonda R, Essex M. Dynamics and timing of in Vivo mutations at Gag residue 242 during primary HIV-1 subtype infection. Virology, 2010; 403(1): 37-46.   

Finkelstein DM, Wang R, Ficociello LH, Schoenfeld DA. A score test for association of a longitudinal marker and an event with missing data. Biometrics, 2010; 66(3): 726-732.

Wang R, Lagakos SW, Gray BJ. Testing and interval estimation of 2-sample survival comparisons with small sizes and unequal censoring. Biostatistics, 2010; 11(4): 676-692.

Wang R, Lagakos SW. Augmented cross-sectional prevalence testing for estimating HIV incidence. Biometrics, 2010; 66(3): 864-874.

Tian L, Wang R, Cai T, Wei LJ. The highest confidence density region and its applications to joint inferences about constrained parameters. Biometrics, 2011, 67(2): 604-610.

Abi-Raad R, Boutrus R, Wang R, Niemierko A, Macdonald S, Smith B, Taghian AG. Patterns and risk factors of locoregional recurrence in T1-T2 node negative breast cancer patients treated with mastectomy: implications for postmastectomy radiotherapy. International Journal of Radiation Oncology, Biology, Physics, 2011, 81(3):e151-7.

Haun JB, Castro CM, Wang R, Pruzinsky V, Marinelli BS, Lee H, Weissleder R.  Micro-NMR for rapid molecular analysis of human cancer cells. Science Translational Medicine, 2011, 3, p.71ra16.

Novitsky V, Wang R, Margolin L, Baca J, Rossenkhan R, Moyo S, van Widenfelt E, Essex M. Transmission of single and multiple viral variants in primary HIV-1 subtype C infection. PLoS One, 2011, 6(20): e16714.

Novitsky V, Ndung’u T, Wang R, Bussmann H, Chonco F, Makhema J, DeGruttola V, Walker BD, Essex M. Extended high viremics: a substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection. AIDS, 2011, 25(12): 1515-1522.

Novitsky V, Wang R, Baca J, Margolin L, McLane MF, Moyo S, van Widenfelt E, Makhema JM, Essex M. Evolutionary gamut of in vivo Gag substitutions during early HIV-1 subtype C infection. Virology 2011, 421(2): 119-28.

Claggett B, Lagakos SW, Wang R. Augmented cross-sectional studies with abbreviated follow-up for estimating HIV incidence. Biometrics 2012, 68(1): 62-74.   (Doctoral student dissertation paper)

Wang R, Bosch R, Benson C, Lederman M. Drug resistant virus has reduced ability to induce immune activation.  The Journal of Acquired Immune Deficiency Syndromes (JAIDS), 2012; 61(4): e60-e63.

Wang R, Ware JH.  Detecting moderator effects using subgroup analyses. Prevention Science 2013, 14(2): 111-120.

Billings ME, Rosen CL, Wang R, Auckley D, Benca R, Foldvary-Schaefer N, Iber C, Zee P, Redline S, Kapur VK. Is the relationship between race and CPAP adherence mediated by sleep duration? Sleep, 2013; 36(2):221-7.

Novitsky V, Wang R, Rossenkhan R, Moyo S, Essex M. Intra-host evolutionary rates in HIV-1C env and gag during primary infection. Infection, Genetics, and Evolution, 2013; 19:361-8.

Wang R, Weng J, Moyo S, Pain D, Barr CD, Maruapua D, Mongwato D, Makhema J, Novitsky V, Essex M. Effect of short-course antenatal Zidovudine and single-dose Nevaripine on the BED capture enzyme immunoassay levels in HIV-1 subtype C infection. AIDS Research and Human Retroviruses, 2013, 29(6): 901-6.

Novitsky V, Bussmann H, Logan A, Moyo S, van Widenfelt E, Okui L, Mmalane M, Baca J, Buck L, Phillips E, Tim D, McLane MF, Lei Q, Wang R, Makhema J, Lockman S, De Gruttola V, Essex M. Phylogenetic relatedness of circulating HIV-1C variants in Mochudi, Botswana. PLoS One, 2013; 8(12):e80589. 

Weinstock T, Rosen CL, Marcus CL, Garetz S, Mitchell RB, Amin R, Paruthi S, Katz E, Arens R, Weng J, Ross K, Chervin RD, Ellenberg S, Wang R, Redline S. Predictors of obstructive sleep apnea severity in adenotonsillectomy candidates. Sleep, 2014; 37(2):261-269. 

Moyo S, LeCuyer T, Wang R, Gaseitsiwe S, Weng J, Musonda R, Bussmann H, Mine M, Engelbrecht S, Makhema J, Marlink R, Baum MK, Novitsky V, Essex M. Evaluation of the false recent classification rates of multi-assay algorithms in estimating HIV-1 subtype C incidence. AIDS Research and Human Retroviruses, 2014; 30(1): 29-36.

Carnegie NB, Wang R, Novitsky V, De Gruttola V. Linkage of viral sequences among HIV-infected village residents in Botswana: estimation of linkage rates in the presence of missing data. PLOS Computational Biology, 2014; 10(1):e1003430. 

Wang R, Goyal R, Lei Q, Essex M, De Gruttola V. Sample size considerations in the design of cluster randomized trials of combination HIV prevention. Clinical Trials, 2014; 11:309-318. 

Gleason K, Shin D, Rueschman M, Weinstock T, Wang R, Ware JH, Mittleman MA, Redline S. Recruitment yields in a randomized controlled study of cardiovascular disease reduction in sleep apnea: impact of mode and source of recruitment.  Sleep, 2014; 37(12):2035-8.

Hicks MH, Li Z (2003) Partner Violence and Major Depression in women: A Community Study of Chinese Americans, Journal of Nervous and Mental Diseases, 2003 Nov; 191(11): 722-9.

Jha AK, Li Z, Orav EJ, Epstein AM. Care in U.S. hospitals – The Hospital Quality Alliance program. N Engl J Med, 2005 Jul 21; 353(3):265-74.

Jha AK, Fisher ES, Li Z, Orav EJ, Epstein AM. Racial trends in the use of major procedures among the elderly. N Engl J Med, 2005 Aug 18; 353(7):683-91.

Liu Y, Berman P, Yip W, Liang H, Meng Q, Qu J, Li Z.  Health care in China: The role of non-government providers. Health Policy.  2005 Aug 19.

Rosenthal MB, Frank RG, Li Z, Epstein AM. Early experience with pay-for-performance: from concept to practice.  JAMA.  2005 Oct 12; 294(14):1788-93.  Was the No. 17th on the 25 most-viewed publications on The Commonwealth Fund Web site in 2005.

Jha AK, Orav EJ, Li Z, Epstein AM.  Concentration and quality of hospitals that care for elderly black patients.  Arch Intern Med. 2007 Jun 11; 167(11):1177-82.

Jha AK, Orav EJ, Li Z, Epstein AM.  The inverse relationship between mortality rates and performance in the hospital quality alliance measures.  Health Aff (Milwood). 2007 Jul-Aug; 26 (4):1104-10.

Gold J, Buonopane RJ, Caggiano RA, Picciotto M, Vogeli C, Kanner NT, Babcock RL,  Li Z, Jellinek M, Drubner SJ, Murphy JM.  Assessing Outcomes in Child Psychiatry.  Am J Manag Care. 2009 Apr; 15 (4): 210-6.

DesRoches C, Donelan K, Buerhaus P, Li Z. Registered Nurses’ Use of Electronic Health Records: Findings from a National Survey, Medscape J Med. 2008; 10(7): 164.

Rosenthal MB, Li Z, Robertson A, Milstein A. Impact of Financial Incentives for Prenatal Care on Birth Outcomes and Spending.  Health Serv Res. 2009 Oct; 44 (5 Pt 1): 1465-79.  Epub 2009 Jul 13.

Simon NM, Herlands NH, Marks EH, Mancini C, Letamendi A., Li Z, Pollack MH, Ameringen MV, Stein MB. Childhood Maltreatment Linked to Greater Symptom Severity and Poorer Quality of Life and Function in Social Anxiety Disorder. Depress Anxiety. 2009; 26 (11): 1027-32.

Li Z, Hicks MH Measuring Depression in Chinese American Women: Validity of the CES-D. Psychiatry Res. 2010 Feb 28; 175 (3): 227-32.  Epub 2009 Dec 14.

Rosenthal MB, Li Z, Milstein A. Do Patients Continue to See Physicians Who Are Removed From a PPO Network? Am J Manag Care. 2009 Oct; 15 (10): 713-9.

Chien A, Li Z, Rosenthal MB. Improving Timely Childhood Immunizations through Pay for Performance in Medicaid Managed Care.  Health Serv Res. 2010 Sep 17.

Rosenthal MB, Schneider E., Friedberg M, Singer SJ, Eastman D, Li Z. Impact of the Rhode Island Multi-Payer Patient-Centered Medical Home Pilot on Health Care Utilization and Quality.  JAMA Internal Medicine. 2014 Nov; 173 (20).

Chien A, Eastman D, Li Z, Rosenthal MB. Impact of a Pay for Performance Program to Improve Diabetes Care in the Safety Net. Preventive Medicine. 11/2012; 55 Suppl: S80-5

Kinney GL, Thomas DSK, Cicutto L, Newman LS, Lutz S, Hokanson JE. (2014) The Protective Effect of Hispanic Ethnicity on Chronic Obstructive Pulmonary Disease Mortality is Mitigated by Smoking Behavior. Journal of Pulmonary and Respiratory Medicine. 4(6):220.

McDonald ML, Cho MH, Sørheim IC, Lutz SM, Castaldi P, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PMA, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Tal-Singer R, Miller BE, Gulsvik A, Casaburi R, Wells JM, Regan EA, Make BJ, Hokanson JE, Lange C, Crapo JD, Beaty TH, Silverman EK, Hersh CP (2014) Common Genetic Variants Associated with Resting Oxygenation in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Bio. 51(5):678-87.

Hersh CP, Make BJ, Lynch DA, Barr RG, Bowler RP, Calverley PM, Castaldi PJ, Cho MH, Coxson HO, DeMeo DL, Foreman MG, Han MK, Harshfield BJ, Hokanson JE, Lutz S, Ramsdell JW, Regan EA, Rennard SI, Schroeder JD, Sciurba FC, Steiner RM, Tal-Singer R, van Beek EJ, Silverman EK, Crapo JD; the COPDGene and ECLIPSE Investigators. (2014) Non-Emphysematous Chronic Obstructive Pulmonary Disease is Associated with Diabetes Mellitus. BMC Pulm Med. 14(1):164.

Marchetti N, Garshick E, Kinney GL, McKenzie A, Stinson D, Lutz SM, Lynch DA, Criner GJ, Silverman EK, Crapo JD, the COPDGene Investigators (2014) Association Between Occupational Exposure and Lung Function, Respiratory Symptoms and High Resolution CT Imaging in COPDGene. Am J Respir Crit Care Med. 190(7):756-62.

Lutz SM, Hokanson JE. (2014) Genetic Influences of Smoking and Clinical Disease: Understanding Behavioral and Biological Pathways with Mediation Analyses. Annals of Thoracic Medicine. 11(7):1082-1083.

Lutz SM, Hokanson JE, Lange C. (2014) An Alternative Hypothesis Testing Strategy for Secondary Phenotype Data in Case-Control Genetic Association Studies. Frontiers in Genetics. 5 (188).

McDonald ML, Diaz AA, Ross JC, San Jose Estepar R, Regan E, Eckbo E, Muralidhar N, Come CE, Cho M, Hersh CP, Lange C, Wouters, E, Coxson H, MacNee B, Rennard S, Lomas D, Agusti A, Celli B, Black-Shinn JL,Kinney GL, Lutz SM, Hokanson JE, Silverman EK and Washko GR. (2014) Quantitative CT Measures of Pectoralis Muscle Area and Disease Severity in COPD: a Cross-Sectional Study. Annals American Thoracic Society. 11(3):326-34.

Hughes G, Cruickshank-Quinn C, Reisdorph R, Lutz S, Reisdorph N, Bowler R, Kechris K. (2014) MSProcess: Summarization, Normalization, and Diagnostics for Processing of Mass Spectrometry Based Metabolomic Data. Bioinformatics. 30(1):133-134.

Lutz SM, Vansteelandt S, Lange C. (2013) Testing for Direct Genetic Effects Using a Screening Step in Family-Based Association Studies. Frontiers in Genetics. 4 (243).

Bowler R, Bahr T, Hughes G, Lutz S, Kim YI, Coldren C, Reisdroph N, Kechris K (2013) Integrative Omics Approach Identifies Interleukin 16 as a Biomarker of Emphysema. OMICS: A Journal of Integrative Biology. 17(12).

Lutz SM, Hokanson JE, Sharma S, Weiss S, Raby B, Lange C. (2013) On the Integration of Expression Profiles and Endo-Phenotypes in Genetic Association Studies: A Bayesian Approach to Determine the Path from Gene to Disease. Open Journal of Genetics. 3(3).

Hersh CP, Washko GR, Estepar RSJ, Lutz S, Friedman PJ, Han MK, Hokanson JE, Judy PF, Lynch DA, Make BJ, Marchetti N, Newell JD, Sciurba FC, Crapo JD, Silverman EK (2013) Paired Inspiratory-Expiratory Chest CT Scans to Assess for Small Airways Disease in COPD. Respiratory Research. 14(42).

Aschard H, Lutz SM, Maus B, Duell EJ, Fingerlin T, Chatterjee N, Kraft P, Van Steen K. (2012) Challenges and Opportunities in Genome-Wide Environmental Interaction (GWEI) studies. Human Genetics. 131(10): 1591-613.