PROMoTeR Assistant Professor, Sharon Lutz and colleagues' article "eQTL mapping of rare variant associations using RNA-seq data: An evaluation of approaches." is published in PLoS One
PROMoTeR Research Scientist II, Joanne Sordillo and colleagues' article "Endotoxin, food allergen sensitization, and food allergy: a complementary epidemiologic and experimental study." is published in Allergy.
PROMoTeR Faculty Joanne Sordillo, Sharon Lutz, PROMoTeR Ann Wu, and colleagues' article "Pharmacometabolomics of Bronchodilator Response in Asthma and the Role of Age-Metabolite Interactions." is published in Metabolites.
PROMoTeR Faculty Marie-France Hivert, Sharon Lutz, and Colleagues' article "Placental DNA Methylation Mediates the Association of Prenatal Maternal Smoking on Birth Weight." is published in American Journal of Epidemiology.
PROMoTeR Associate Director Christine Lu and Colleagues' article "Clinical Molecular Marker Testing Data Capture to Promote Precision Medicine Research Within the Cancer Research Network." is published in Journal of Clinical Cancer Informatics.
PROMoTeR Center hosted Dr. Paul W. Franks, PhD at our most recent PROMoTeR Center Seminar! Dr. Franks spoke in his work in "Precision Prevention in Obesity and Diabetes"
PROMoTeR Research Scientist II, Joanne Sordillo and colleagues' article "Prenatal Oxidative Balance and Risk of Asthma and Allergic Disease in Adolescence." is published in The Journal of Allergy and Clinical Immunology
PROMoTeR Assistant Professor Sharon Lutz and colleagues' article "Effect of population stratification on SNP-by-environment interaction." is published in Genetic Epidemiology.
PROMoTeR Research Scientist, Joanne Sordillo and colleagues' article "Indoor Bacterial Microbiota and the Development of Asthma by 10.5 years of age." is published in The Journal of Allergy and Clinical Immunology
PROMoTeR Associate Professor Maryam Asgari and Colleagues' article "Correlates of multiple cutaneous squamous cell carcinoma: a retrospective cohort study." is published in Journal of the American Academy of Dermatology
PROMoTeR Associate Director Christine Lu and Colleagues' article "Variation in patterns of health care before suicide: A population case-control study." is published in Preventive Medicine
PROMoTeR Associate Professor Marie-France Hivert, Research Scientist Joanne Sordillo, and Colleagues' article "The nasal methylome as a biomarker for asthma and airway inflammation in children." is published in Nature Communications.
PROMoTeR Associate Professor Marie-France Hivert, Research Scientist Joanne Sordillo, and Colleagues' article "Metabolic trajectories across early adolescence: differences by sex, weight, pubertal status, and race/ethnicity." is published in Annals of Human Biology.
PROMoTeR Research Fellow Rachele Hendricks-Sturrup, Collaborator Kathleen Mazor, Associate Professor Christine Lu, and Colleagues' article "Barriers and Facilitators to Genetic Testing for Familial Hypercholesterolemia in the United States: A Review" published in Journal of Personalized Medicine.
Christine Lu and colleagues' article "Diagnosed Mental Health Conditions and Risk of Suicide Mortality." Is published in Psychiatric Services
Marie-France Hivert and colleagues' article "Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors." Is published in Nature Genetics
PROMoTeR Collaborator Jennifer Yeh, PhD was featured in Healio discussing her presentation at this years annual ASCO meeting focused on Population- Base Genetic Testing of Newborns highlighting the work from the PreEMPT project.
Christine Lu and colleagues' article "Assessing the Joint Value of Genomic-Based Diagnostic Tests and Gene Therapies." Is published in the Journal of Personalized Medicine.
Christine Lu and colleagues' article "Impact of ICD-10-CM Transition on Mental Health Diagnoses Recording." Is published in The Journal for Electronic Health Data and Methods.
PROMoTeR research fellow Rachele Hendricks-Sturrup and Christine Lu's publication "Direct-to-Consumer Genetic Testing Data Privacy: Key Concerns and Recommendations Based on Consumer Perspectives." Is Published in the Journal of Personalized Medicine.
PROMoTeR research fellow Rachele Hendricks-Sturrup, DHSc, MSc, MA give this weeks Brown Bag Seminar talk. Rachele's talk focused on Direct- to- Consumer Genetic Testing (DTC-GT): Current Events & Expectations of Privacy and Nondiscrimination. Great work Rachele!
Christine Lu, Maryam Asgari, and colleagues' publication "The Impact of the Orphan Drug Act on FDA-Approved Therapies for Rare Skin Diseases and Skin-Related Cancers" is published in Journal of the American Academy of Dermatology
PROMoTeR is now on Twitter! Check out our page and make sure to follow @PROMoTeR_DPM
Christine Lu and colleagues' publication "The Healthcare Systems Research Network (HCSRN) as an Environment for Dissemination and Implementation Research: A Case Study of Developing a Multi-Site Research Study in Precision Medicine" is published in The Journal of Electronic Health Data and Methods.
Maryam Asgari and colleagues' publication "Closing the Gender Wage Gap and Achieving Professional Equity in Medicine" is published in JAMA Network.
Ann Wu and colleagues' publication "A Group Visit for High-Risk Pediatric Asthma Patients: A Quality Improvement Initiative to Improve Asthma Care" is published in Sage Journal.
Rachele Hendricks-Sturrup and Christine Lu's publication "Direct-to-Consumer Genetic Testing and Potential Loopholes in Protecting Consumer Privacy and Nondiscrimination" is published in JAMA Network!
Many thanks to our May 2019 PROMoTeR Center guest speaker Megan Doerr, MS, LGC. She presented on “Case Studies in Open Models of Precision Medicine: from consent to publication”.
Rachele Hendricks-Sturrup and Christine Lu's publication "Understanding Implementation Challenges to Genetic Testing for Familial Hypercholesterolemia in the United States" is featured in the Journal for Personalized Medicine.
Dr. Leland Hull, MD, MPH visited DPM on January 24th and presented "Gene-based prescribing in the Department of Veterans Affairs" as a guest speaker for the PROMoTeR Center.
Ann Wu, Joanne Sordillo, Sharon Lutz and colleagues' publication "Longitudinal analysis of bronchodilator response in asthmatics and effect modification of age‐related trends by genotype" is featured in Pediatric Pulmonology.
"Large-scale, multi-ethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults" was published in the Journal of Allergy and Clinical Immunology.
"Current Status and Future Opportunities in Lung Precision Medicine Research with a Focus on Biomarkers. An American Thoracic Society/National Heart, Lung, and Blood Institute Research Statement" was published in the American Journal of Respiratory and Critical Care Medicine.
Chris Lu and colleagues' publication "Implementing universal Lynch syndrome screening (IMPULSS): protocol for a multi-site study to identify strategies to implement, adapt, and sustain genomic medicine programs in different organizational contexts." is featured in BMC Health Services Research.
On October 26, 2018 Dr. Ann Wu presented "Asthma Pharmacogenetics from a Health Services Researcher's Point of View" at the Harvard School of Public Health's Program in Genetic Epidemiology and Statistical Genetics Seminar Series.
ChERP and PROMoTeR are delighted to welcome Pamela McMahon, PhD to DPM! She has a PhD in Health Policy and Decision Science from Harvard and was an assistant professor in the Department of Radiology at MGH where she was the PI of the Cancer Intervention and Surveillance Modeling Network Lung Group. Most recently, she was a Managing Scientist at Exponent, Inc. She will serve as Project Director of Ann Wu’s Precision Medicine Policy and Treatment (PreEMT) Model projects. She is a person with many talents and is also an amazing artist!
Ann Wu, Chris Lu and colleagues' publication "The Implementation Process for Pharmacogenomic Testing for Cancer-Targeted Therapies." is featured in the Journal of Personalized Medicine.
Joanne Sordillo, Peter Kraft, Ann Wu and Maryam Asgari's publication "Quantifying the Polygenic Contribution to Cutaneous Squamous Cell Carcinoma Risk." is featured in the Journal of Investigative Dermatology.
Maryam Asgari and colleagues published an article in Cancer Epidemiology, Biomarkers and Prevention entitled, "Common Mitochondrial Haplogroups and Cutaneous Squamous Cell Carcinoma Risk."
Joanne Sordillo and Emily Oken's publication "Relation of Prenatal Air Pollutant and Nutritional Exposures with Biomarkers of Allergic Disease in Adolescence." was featured in Scientific Reports.
Angel Mak, Esteban Burchard, Ann Wu and colleagues published an article in the American Journal of Respiratory and Critical Care Medicine entitled, "Whole genome sequencing of pharmacogenetic drug response in racially diverse children with asthma."
Maryam Asgari, Eric Jorgenson and colleagues published an article in Cancer Immunology, Immunotherapy entitled, "Genetic variants in the HLA class II region associated with risk of cutaneous squamous cell carcinoma."
Ann Wu, Emily Oken, Joanne Sordillo, Marie-France and colleagues published an article in Clinical and Experimental Allergy entitled, "Plasma Metabolite Profiles in Children with Current Asthma."
Christine Lu, Ann Wu and colleagues published an article in the Journal of Personalized Medicine entitled, "Insurance Coverage Policies for Pharmacogenomic and Multi-Gene Testing for Cancer."
Guest speaker, Dr. Eric Jorgenson, presented his talk "A View to Precision Medicine: Findings from the Research Program on Genes, Environment, and Health" on Monday May 7th.
Christine Lu and colleagues published an article in Genetics in Medicine entitled, "Short-term costs of integrating whole-genome sequencing into primary care and cardiology settings: a pilot randomized trial." The paper has been featured by the STAT news.
We are happy to welcome Michael Gooch, PhD to the PROMoTeR Center as a Programmer. He comes to us from UConn Health where he earned a PhD in Biomedical Science Genetics and Genome Sciences. Michael will be working with Ann Wu on her ADAPT and PreEMT studies. We are thrilled he has joined our team!
On February 15th, the PROMoTeR Center had guest speaker, Dr. Blanca Himes, visit. She presented on "Biomedical Informatics Approaches to Study Asthma".
On Monday December 11th, the PROMoTeR Center had a seminar featuring Dr. Fred Tabung. He presented on "The Inflammatory and Insulinemic Potential of Diet and Risk of Cancer".
On Monday December 4th, the PROMoTeR Center had a seminar featuring Dr. Nilah Ioannidis. She presented on "Clinical interpretation of genetic variation: Statistical methods and application to cutaneous squamous cell carcinoma".
PROMoTeR Center group presented their work to the Department
Christine Lu was invited to give a presentation, titled “A Model for Accelerating Evidence Generation for Genomic Technologies in the Context of a Learning Health Care System” at the "Implementing and Evaluating Genomic Screening Programs in Health Care Systems – A Workshop", National Academies of Sciences, Engineering and Medicine in Washington DC, November 1, 2017.
Christine Lu was invited as the Chair and a panelist of a session entitled, “Value based frameworks for precision medicine,” at the Evidence Pricing & Market Access World Congress, Philadelphia, PA, October 10-11, 2017.
Christine Lu was invited as part of a panel session “Putting the G in genome: Financial sustainability of genomic medicine” at the Festival of Genomics, Boston, MA, 3-4 October, 2017.
On Monday September 25th, the PROMoTeR Center will had a seminar featuring Dr. Sharon Lutz. She presented on "Approaches to Incorporate and Understand the Path from Gene to Disease."
Congratulations to Ann Wu, MD MPH (Principal Investigator), Chris Lu, MSc PhD, and Natasha Stout, PhD, on receiving an R01 funded by the National Institute of Child, Health, and Human Development. In the grant, the Precision Medicine Treatment (PreEMT) Model, Dr. Wu and HPHC co-investigators, will develop a computer model capable of simulating short- and long-term clinical benefits and estimating the cost-effectiveness of integrating different genome screening strategies into clinical care for healthy or high-risk newborns for a wide variety of heritable conditions. With this model, they will synthesize the best available clinical, epidemiologic, and economic data on genetic variants present at birth for a wide variety of genetically-driven childhood conditions to project health outcomes, and provide a dynamic tool to evaluate evolving knowledge in the area of genomics and precision medicine in the United States over the next decade.
Christine Lu and colleagues published an article in Genetics in Medicine entitled, "A proposed approach to accelerate evidence generation for genomic-based technologies in the context of a learning health system." The paper has been featured by the Centers for Disease Control and Prevention, Genomics and Health Impact Blog.
Ann Wu organized a workshop to create "An Official Research Statement of the ATS and NHLBI: Current Status and Future Directions in Lung Precision Medicine Research." Dr. Wu is pictured with patient speaker, Maki Inada, a non-smoker, who beat non small cell lung cancer with the help of precision medicine.
Esteban Burchard, MD MPH, advisor on President Obama's Precision Medicine Initiative working group, visited with the PROMoTeR Center.
Ann Wu participated in a Radcliffe Institute Seminar on Redesigning Health Systems for Precision Medicine.
Peter Kraft, Professor of Epidemiology at the Harvard School of Public Health, visited with members of the PROMoTeR Center.
Faculty from the PROMoTeR Center (Ann Wu, Christine Lu, and Maryam Asgari) attend the Harvard Medical School Leadership Development Course for Physicians and Scientists.
Christine Lu was invited to give a presentation, titled “Genomic Medicine: Access, Coverage and Ethics” at the National Academies of Sciences, Engineering and Medicine (formerly Institute of Medicine) in March in Washington DC.