Cost-effectiveness of colorectal cancer screening.

View Abstract

PURPOSE

To determine the most cost-effective colorectal cancer screening strategy costing less than $100,000 per life-year saved and to determine how available strategies compare with each other.

MATERIALS AND METHODS

Standardized methods were used to calculate incremental cost-effectiveness ratios (ICERs) from published estimates of cost and effectiveness of colorectal cancer screening strategies, and the direction and magnitude of any effect on the ratio from parameter estimate adjustments based on literature values were estimated.

RESULTS

Strategies in which double-contrast barium enema examination was performed emerged as optimal from all studies included. In average-risk individuals, screening with double-contrast barium enema examination every 3 years, or every 5 years with annual fecal occult blood testing, had an ICER of less than $55,600 per life-year saved. However, double-contrast barium enema examination screening every 3 years plus annual fecal occult blood testing had an ICER of more than $100,000 per life-year saved. Colonoscopic screening had an ICER of more than $100,000 per life-year saved, was dominated by other screening strategies, and offered less benefit than did double-contrast barium enema examination screening.

CONCLUSION

Double-contrast barium enema examination can be a cost-effective component of colorectal cancer screening, but further modeling efforts are necessary.

Investigators
Abbreviation
Radiology
Publication Date
2001-04-01
Volume
219
Issue
1
Page Numbers
44-50
Pubmed ID
11274533
Medium
Print
Full Title
Cost-effectiveness of colorectal cancer screening.
Authors
McMahon PM, Bosch JL, Gleason S, Halpern EF, Lester JS, Gazelle GS