Parametric g-formula implementations for causal survival analyses.

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The g-formula can be used to estimate the survival curve under a sustained treatment strategy. Two available estimators of the g-formula are non-iterative conditional expectation and iterative conditional expectation. We propose a version of the iterative conditional expectation estimator and describe its procedures for deterministic and random treatment strategies. Also, because little is known about the comparative performance of non-iterative and iterative conditional expectation estimators, we explore their relative efficiency via simulation studies. Our simulations show that, in the absence of model misspecification and unmeasured confounding, our proposed iterative conditional expectation estimator and the non-iterative conditional expectation estimator are similarly efficient, and that both are at least as efficient as the classical iterative conditional expectation estimator. We describe an application of both non-iterative and iterative conditional expectation to answer "when to start" treatment questions using data from the HIV-CAUSAL Collaboration. This article is protected by copyright. All rights reserved.

Investigators
Abbreviation
Biometrics
Publication Date
2020-06-26
Pubmed ID
32588909
Medium
Print-Electronic
Full Title
Parametric g-formula implementations for causal survival analyses.
Authors
Wen L, Young JG, Robins JM, Hernán MA