Studying Adsorption and Cellular Toxicity of Boron Nitride Nanostructure versus Melphalan Anti-ovarian Cancer Drug.

View Abstract

BACKGROUND

Inclusion of anticancer drugs into biocompatible nanoparticulate carriers decreases the general toxicity and improves the efficacy of clinical treatments due to the reduction of soluble circulating free drug.

METHODS

In addition, removal of emerging drug contaminants from wastewaters is a necessity that should be seriously attended. Boron nitride (BN) is choice in drug delivery because of many surprising properties. Here, boron nitride nanoparticles are prepared, characterized by Fourier-transform infrared spectroscopy (FT-IR) and x-ray diffraction (XRD) and used in the delivery of melphalan anti-cancer drug.

RESULTS

Then, density functional theory (DFT) calculations are carried out to study adsorption of this drug on the surface of pure boron nitride fullerene via familiar hybrid functionals B3LYP and B3PW91. In addition, the polarizable continuum model (PCM) calculations show that BN is stable in water.

CONCLUSION

Finally, the in vitro cellular toxicity and viability of BN nanoparticles was examined on ES-2 cancer cells. The inhibitory dose IC50 of the material confirmed an acceptable cytotoxicity and nanoparticles affected the average growth of ES-2 cancer cells.

Investigators
Abbreviation
Curr Mol Med
Publication Date
2021-01-10
Pubmed ID
33430730
Medium
Print-Electronic
Full Title
Studying Adsorption and Cellular Toxicity of Boron Nitride Nanostructure versus Melphalan Anti-ovarian Cancer Drug.
Authors
Fu M, Tayebee R, Saberi S, Nourbakhsh N, Esmaeili E, Maleki B, Vatanpour HR