Vaccine-related varicella-zoster rash in a hospitalized immunocompetent patient.

View Abstract

An immunocompetent health care worker with no known history of varicella-zoster virus (VZV) disease was exposed to a patient with herpes zoster and was immunized 2 days later. Twenty-seven days after receiving the varicella vaccine, while hospitalized, she developed a disseminated rash. This exposure and subsequent development of symptoms posed infection control challenges. A polymerase chain reaction analysis of her vesicular fluid was positive for vaccine-type VZV, and a blood specimen collected before vaccination demonstrated a positive VZV titer by the fluorescent antibody to membrane antigen test. To the best of our knowledge, there have been no previous reports of an immunocompetent seropositive person developing vaccine-type VZV after receiving the vaccine.

Investigators
Abbreviation
Am J Infect Control
Publication Date
2010-12-26
Volume
39
Issue
3
Page Numbers
247-9
Pubmed ID
21269735
Medium
Print-Electronic
Full Title
Vaccine-related varicella-zoster rash in a hospitalized immunocompetent patient.
Authors
Bernstein P, Furuya Y, Steinberg S, Scully B, Larussa P, Gershon AA