ABATE

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ABATE Infection Project (NIH Collaboratory Demonstration Project)

Healthcare-associated infections remain one of the 10 most frequent causes of death in the United States and incur between $6.5-10 billion dollars of healthcare costs each year. Most infections result from common bacteria that normally live on the skin or in the nose and which overcome the body’s normal defenses because of invasive medical devices, surgical incisions, or the physiologic effects of hospitalization. Studies in intensive care units (ICUs) indicate that decolonization of patients’ skin with chlorhexidine, and nares with mupirocin can prevent HAIs. However, evidence is lacking about the effectiveness of decolonization in non-ICU settings, where the majority of HAIs occur, and where medical care, risk of infection, patient-to-patient interactions, pathogen transmission, and bathing practices differ considerably from ICU settings.

The ABATE Infection Trial (Addressing Bioburden while Admitted To Eliminate Infection) will randomize 50+ hospitals to routine care vs universal decolonization. This trial will provide essential information to determine whether routine decolonization should become standard practice for 40 million patients hospitalized each year in the United States alone. Alternatively, it will suggest that tailored strategies distinct from those effective in ICU settings are needed for patients in non-critical care settings.


Principal Investigator: Grace Lee, MD, MPH

Funder: National Institute of Health


 

Abate II Ethics Supplement

This project explores the attitudes, beliefs, and actions of patients, leaders of healthcare quality improvement programs, and chairs of research ethical review boards regarding what constitutes expected improvements in healthcare and what constitutes research. Specifically, it will compare and contrast the expectation that healthcare facilities continue to improve medical care and define best strategies for patient health and safety with the regulatory requirements of research studies with similar goals. The goal is to inform and improve the process by which continued advancements in medical care are made.

 

Please refer HERE for more information regarding ABATE


Principal Investigator: Grace Lee, MD, MPH

Funder: National Institute of Health