NIH Collaboratory

Supported by the Common Fund at the National Institutes of Health, the Health Care Systems Research Collaboratory supports the design and rapid execution of pragmatic clinical trial Demonstration Projects that address questions of major public health importance and engage healthcare delivery systems in research partnerships. These projects help to establish best practices and provide proof of concept for innovative designs in pragmatic clinical research.

Harvard Pilgrim Health Care is part of the Collaboratory’s Coordinating Center. Harvard Pilgrim leads the development and maintenance of the Collaboratory’s Distributed Research Network, which provides a mechanism for investigators funded by NIH and other not-for-profit sponsors to conduct research in partnership with many of the nation’s largest health plans.

Richard Platt, MD, MSc is the Harvard Pilgrim Health Care site-Principal Investigator. Additional members of the team include Jeffrey Brown, PhD and Alicia Muzzi, MPH.

Related Publications

Jutkowitz E, Bynum JPW, Mitchell SL, et al. Diagnosed prevalence of Alzheimer’s disease and related dementias in Medicare Advantage plans. Alzheimers Dement (Amst). 2020;12(1). doi:10.1002/dad2.12048

Simon GE, Platt R, Hernandez AF. Evidence from Pragmatic Trials during Routine Care — Slouching toward a Learning Health System. New England Journal of Medicine. 2020;382(16):1488-1491. doi:10.1056/NEJMp1915448

Marsolo KA, Brown JS, Hernandez AF, et al. Considerations for using distributed research networks to conduct aspects of randomized trials. Contemporary Clinical Trials Communications. 2020;17:100515. doi:10.1016/j.conctc.2019.100515

Panozzo CA, Curtis LH, Marshall J, et al. Incidence of statin use in older adults with and without cardiovascular disease and diabetes mellitus, January 2008- March 2018. PLoS One. 2019;14(12). doi:10.1371/journal.pone.0223515

Raman SR, Brown JS, Curtis LH, et al. Cancer Screening Results and Follow-up Using Routinely Collected Electronic Health Data: Estimates for Breast, Colon, and Cervical Cancer Screenings. J Gen Intern Med. 2019;34(3):341-343. doi:10.1007/s11606-018-4697-y

Related Links

Principal Investigator

Richard Platt, MD, MSc


National Institutes of Health