PROBIT I: Birth - 12 mos
June 1996 - December 1997
During the birth hospitalization, study obstetricians collected information from mothers on background and birth characteristics. At 1, 2, 3, 6, 9 and 12 months of age, study pediatricians assessed participants’ growth and collected clinical data from polyclinic records.
Intention to treat analyses of PROBIT I data demonstrated that the randomized intervention produced higher rates of breastfeeding exclusivity and duration; infants at the intervention sites were significantly more likely to be exclusively breastfed at 3 months (43.3% vs. 6.4%, p<0.001) and at 6 months (7.9% versus 0.6%, p=0.01) when compared to infants at the control sites. Infants at the intervention sites were also less likely to have 1 or more gastrointestinal tract infections (9.1% vs. 13.2%; adjusted OR, 0.60; 95% CI, 0.40-0.91) or atopic eczema (3.3% vs 6.3%; adjusted OR, 0.54; 05% CI, 0.31-0.95) in their first year of life (Kramer et al, JAMA 2001). There were no demonstrable adverse effects associated with exclusive breastfeeding for 6 months (Kramer et al, Am J Clin Nutr, 2003). In case control studies nested within the larger PROBIT study, we examined the hypothesis that prior gastrointestinal infection could protect against atopic eczema or wheeze among infants; we found no evidence to support this hypothesis (Kramer et al, Clin Exp Allergy, 2004).
Michael Kramer, MD: McGill University, Quebec, Canada
Belarus: Zinaida Sevkovskaya, MD; Irina Dzikovich, MD, PhD; Irina Vanilovich, MD; Vyacheslav Zubovich, MD, PhD; Dimitri Mknuik, MD, PhD; Elena Gluchanina, MD; Viktor Dombrovskiy, MD, PhD; Anatoly Ustinovitch, MD, PhD; Tamara Kot, MD; Natalia Bogdanovich, MD, PhD; Lydia Ovchinikova, RN
- PROBIT I Interview Questionnaire Data Forms
- Promotion of breastfeeding intervention trial (PROBIT): a cluster-randomized trial in the Republic of Belarus. Design, follow-up, and data validation
- Promotion of Breastfeeding Intervention Trial (PROBIT): a randomized trial in the Republic of Belarus
- Infant growth and health outcomes associated with 3 compared with 6 mo of exclusive breastfeeding
- Does previous infection protect against atopic eczema and recurrent wheeze in pregnancy?