PCORnet: The National Patient-Centered Clinical Research Network

PCORnet, the National Patient-Centered Clinical Research Network, is a national resource that offers the kind of research ecosystem that has long been pursued: a fully integrated network where vast, highly representative health data, research expertise, and patient insights are built-in and accessible from the very start. The infrastructure of PCORnet is well established, meaning that the community knows how to maximize the value of these connections to deliver fast, trustworthy answers that advance public health.

PCORnet's Coordinating Center is composed of three organizations working to lead the network’s data and engagement activities and support the overall network infrastructure: Duke Clinical Research Institute (DCRI), Harvard Pilgrim Health Care Institute (HPHCI), and Academy Health. DCRI and HPHCI focus on data and convening activities while Academy Health leads PCORnet engagement. Both DCRI and HPHCI have expertise developing infrastructure to support the Networks' conduct of patient-centered comparative effectiveness research and have collaborated to create and manage large, complex research networks using electronic health data to support clinical trials, comparative effectiveness research, health policy, and health services research. Richard Platt, MD, MSc and Jason Block, MD, MPH are the HPHCI co-Principal Investigators of the PCORnet Coordinating Center team.


PCORnet is uniquely positioned to offer the real-world evidence essential for answering the clinical questions that impact peoples' lives and support studies addressing major public health issues (e.g., obesity, opioid crisis) while ensuring patient participation in research. Learn more here.


With access to data from everyday encounters with more than 70 million people across the U.S., users of PCORnet have potential insights at their fingertips. These data are accessible via a distributed research network model of nine large Clinical Research Networks (CRNs), based in healthcare systems such as hospitals, integrated delivery systems, and federally qualified health centers, and two Health Plan Research Networks (HPRNs), with claims data from national insurers, all facilitated by the Coordinating Center.

PCORnet Network Partners not only source data, but also propel patient-centered research forward. PCORnet-partnered CRNs and HPRNs include the nation’s leading clinical researchers whose collective knowledge and experiences empower and support users of the Network.


When patients and caregivers take an active role in research, outcomes improve. That’s why every PCORnet-enabled effort broadly embeds the voice of patients and those who care for them. Patients and caregivers serve as members of PCORnet’s governance, participate in its committees, and provide leadership across every stage of research. Read more about PCORnet’s engagement strategy here.

How it all works

Questions for PCORnet start at the Front Door. The Front Door is a central gateway point for anyone seeking to use PCORnet’s infrastructure and collaborate on patient-centered research. Interested parties can submit a request to the Front Door and a member of the PCORnet Coordinating Center will set up a consultation to clarify the request outline next steps that may include a request for collaboration and/or a Network-wide query.

Related Links

PCORnet Website

For more information: frontdoor@pcornet.org

Principal Investigators

Richard Platt, MD, MSc and Jason Block, MD, MPH