ASPE T-MSIS
Funder(s): Assistant Secretary for Planning and Evaluation (ASPE); United States Food and Drug Administration (FDA)
PI: Sengwee Darren Toh
Year Initiated: 2021
Project Summary
This is a joint agency project involving the Food and Drug Administration (FDA) and National Institutes of Health/ National Library of Medicine (NIH/NLM) that addresses the Patient-Centered Outcomes Research (PCOR) priority to expand data capacity or data infrastructure for conducting research that informs decisions about the effectiveness of health interventions used in the Medicaid and Children's Health Insurance Programs.
This project aims to develop and publish open source code to format T-MSIS Research Identifiable File (RIFs) to the Sentinel CDM in tandem with NLM’s formatting of the T-MSIS RIFs to the Medical Outcomes Partnership (OMOP) and Common Data Models (CDMs). Data quality will be characterized using a harmonized Data Quality Assessment Framework for electronic healthcare data that was developed in a previously funded OS-PCORTF project. To illustrate the benefits of CDM transformation, open source tools will be used to conduct several studies of public health importance, such as studies of maternal mortality and adherence to clinical guidelines for perinatal testing.
Additionally, the project will assess the feasibility of using Fast Healthcare Interoperability Resources (FHIR) and Application Programming Interfaces (APIs) to link Electronic Health Record (EHR) data to T-MSIS claims data.
Lastly, the project will ensure stakeholder engagement and sustainability via a Technical Expert Panel (TEP) to provide guidance on the data quality metrics, the PCOR demonstration projects, and development of a series of training materials. The goal of the training materials is to ensure findings are optimally disseminated to the Medicaid research community to lead to greater utilization of the CDM translation code and use of T-MSIS for patient-centered outcomes research in Sentinel and OMOP ecosystems.
ASPE T-MSIS Major Tasks
Develop open source code to format the T-MSIS data into the Sentinel and Observational Medical Outcomes Partnership (OMOP) Common Data Models (CDMs).
Leverage the ASPE funded data quality metrics model to characterize each CDM-formatted version.
Develop open-source code to create a mother-infant linkage in the Sentinel CDM to support several Sentinel analyses on maternal health.
Conduct one or more demonstration studies assessing the harms and benefits of an aspect of maternal health using the transformed T-MSIS dataset and Sentinel analytic tools. The FDA-led workgroup will include participation from CDC/NCHHSTP, CDC/NCBDDD, NIH/NICHD and HRSA.
Conduct one or more demonstration studies assessing the harms and benefits of an aspect of maternal health using the transformed T-MSIS dataset and Sentinel analytic tools. The FDA-led workgroup will include participation from CDC/NCHHSTP, CDC/NCBDDD, NIH/NICHD and HRSA.
Engage stakeholders and create sustainability by:
- Establishing a TEP with relevant expertise in the Medicaid program, T-MSIS data, or patient-centered outcomes research to provide non-binding guidance from an end-user’s perspective on the data quality metrics selected in Task 2, potential PCOR demonstration projects using the new T-MSIS dataset in Task 4, and the structure of the training materials
- Developing a webinar series to train Medicaid researchers on the new data transformation tools and disseminate major project findings, which can be found on the Sentinel Initiative YouTube Channel.
Keep up with project updates
For the latest on deliverables, who is behind ASPE T-MSIS, and more, visit the Sentinel website.