PROBIT III

January 2008-December 2010

Researchers conducted additional follow-up at age 11.5 years, collecting data from 13,879 children, representing 81% of the original participants, on growth, adiposity, blood pressure, blood glucose, insulin, and other markers of cardiometabolic disease risk.

Intention-to-treat analyses showed that the randomized intervention did not affect adiposity, insulin-like growth factor-I, or other cardiometabolic health outcomes. However, the intervention was associated with a reduction in problematic eating attitudes, as measured by the Children's Eating Attitude Test (ChEAT).

Further follow-up found that problematic eating attitudes in mid-childhood were associated with the development of obesity in adolescence, a finding with potentially important public health implications. Among PROBIT mothers, the intervention did not result in meaningful reductions in adiposity or blood pressure 11.5 years after birth.

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  • 2008-2010:
    Emily Oken, MD, MPH: Harvard Pilgrim Health Care Institute, United States of America
    Michael Kramer, MD: McGill University, Quebec, Canada
    Richard M. Martin, B.Med.Sci., B.M., B.S., M.Sc., M.R.C.G.P., PhD: University of Bristol, United Kingdom

  • 2008-2010:
    Belarus: Konstantin Vilchuck, MD; Natalia Bogdanovich, MD; Natalia Sergeichick, PhD; Nina Gusina, PhD; Oleg Skugarevsky, MD; Lydia Matush, MD 
    United States:  Matthew Gillman, MD, SM
    United Kingdom:  George Davey Smith, M.A., M.D., B.Chir., M.Sc.