Our researchers are leading seminal work on pharmacogenetic testing for asthma, performing genetic epidemiological studies that focus on large, real-life population. Highlights include:
A study that evaluated the effectiveness of recently developed pharmacogenetic tests that predict which patients are at highest risk for not responding to the two most commonly used medications for asthma, B2-agonist and inhaled corticosteroids.
A current study to validate a pharmacogenetic test using a cohort of asthma patients who have been treated with inhaled corticosteroids.
Related News and Recent Publications
- Kelly RS, Dahlin A, McGeachie MJ, et al. Asthma Metabolomics and the Potential for Integrative Omics in Research and the Clinic. CHEST. Feb 2017;151(2):262-277.
- McGeachie MJ, Dahlin A, Qiu W, Croteau-Chonka DC, Savage J, Wu AC, Wan ES, Sordillo JE, Al-Garawi A, Martinez FD, Strunk RC, Lemanske RF Jr, Liu AH, Raby BA, Weiss S, Clish CB, Lasky-Su JA. The metabolomics of asthma control: a promising link between genetics and disease. Immun Inflamm Dis. 2015 Sep;3(3):224-38. Epub 2015 May 7.
- McGeachie MJ, Wu AC, Tse SM, Clemmer GL, Sordillo J, Himes BE, Lasky-Su J, Chase RP, Martinez FD, Weeke P, Shaffer CM, Xu H, Denny JC, Roden DM, Panettieri RA Jr, Raby BA, Weiss ST, Tantisira KG. CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies. J Allergy Clin Immunol. 2015 Jun 12. [Epub ahead of print]
- Clemmer GL, Wu AC, Rosner B, McGeachie MJ, Litonjua AA, Tantisira KG, Weiss ST. Measuring the corticosteroid responsiveness endophenotype in asthmatic patients. J Allergy Clin Immunol. 2015 Aug;136(2):274-81.e8. Epub 2015 May 5.
- Wu AC, Gay C, Rett MD, Stout N, Weiss ST, Fuhlbrigge AL. Pharmacogenomic test that predicts response to inhaled corticosteroids in adults with asthma likely to be cost-saving. Pharmacogenomics. 2015;16(6):591-600. Epub 2015 Apr 16.
For more information on the Center's work please contact Kelly Horan.