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September 2021

Joanne Sordillo, Sharon Lutz, Ann Wu, and colleagues’ article “A polygenic risk score for asthma in a large racially diverse population” is published in Clinical & Experimental Allergy.

Maryam Asgari and colleagues’ article “Consensus-Based Recommendations on the Prevention of Squamous Cell Carcinoma in Solid Organ Transplant Recipients A Delphi Consensus Statement” is published in JAMA Dermatology.

Sharon Lutz and colleagues’ article “Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease” is published in Journal of Cachexia, Sarcopenia and Muscle.

Marie-France Hivert and colleagues’ article “Sustainable food systems and nutrition in the 21st century: A report from the 22nd annual harvard nutrition obesity symposium” is published in The American Journal of Clinical Nutrition.

Marie-France Hivert and colleagues’ article “Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence” is published in Obesity.

PROMoTeR welcomed a new member in September!

Madison Hickingbotham - Research Assistant

August 2021

Kurt Christensen and colleagues’ article “Effects of participation in a U.S. trial of newborn genomic sequencing on parents at risk for depression” is published in Journal of Genetic Counseling.

Marie-France Hivert and colleagues’ article “Early Life Exposure to Green Space and Mid-childhood Cognition in the Project Viva Cohort (Massachusetts, USA)” is published in American Journal of Epidemiology.

Chris Lu and colleagues’ article “The Effectiveness and Safety of Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer Patients With Stage III/IV: A Multicenter Study” is published in Frontiers in Oncology.

Marie-France Hivert and colleagues’ article “Placental miR-3940-3p is associated with maternal insulin resistance in late pregnancy” is published in The Journal of Clinical Endocrinology & Metabolism.

Sharon Lutz, Marie-France Hivert, and colleagues’ article “Early-pregnancy maternal body mass index is associated with common DNA methylation markers in cord blood and placenta: a paired-tissue epigenome-wide association study” is published in Epigenetics.

Marie-France Hivert and colleagues’ article “Physiologic Subtypes of Gestational Glucose Intolerance and Risk of Adverse Pregnancy Outcomes” is published in American Journal of Obstetrics and Gynecology.

Kurt Christensen and colleagues’ article “Psychosocial Effect of Newborn Genomic Sequencing on Families in the BabySeq Project: A Randomized Clinical Trial” is published in JAMA Pediatrics.

Ann Wu and colleagues’ article “Validation of the Association of Oral Corticosteroid Bursts With Adverse Events in Children-Reply” is published in JAMA Pediatrics.

Marie-France Hivert and colleagues’ article “Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth” is published in Nature Communications.

Kurt Christensen and colleagues’ article “Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients” is published in NPJ Genomic Medicine.

July 2021

Sharon Lutz and colleagues article “Seasonal Variation in miR-328-3p and let-7d-3p Are Associated With Seasonal Allergies and Asthma Symptoms in Children” is published in Allergy, Asthma & Immunology Research.

Ann Wu and colleagues' article “Creative Approaches for Assessing Long-term Outcomes in Children” is published in Pediatrics.

Marie-France Hivert and colleagues’ article “Genetic Interactions with Intrauterine Diabetes Exposure in Relation to Obesity: The EPOCH and Project Viva Studies” is published in Pediatric Reports.

Marie-France Hivert and colleagues’ “Associations of maternal insulin resistance during pregnancy and offspring inflammation at birth and at 5 years of age: A prospective study in the Gen3G cohort” is published in Cytokine.

Emilie Zoltick and colleagues’ article “Sugar-sweetened beverage, artificially sweetened beverage and sugar intake and colorectal cancer survival” is published in British Journal of Cancer.

Maryam Asgari and colleagues’ article “The effectiveness of an electronic clinical decision support tool embedded into the patient medical record at the point of care to guide Mohs surgery utilization: A cohort study” is published in Journal of the American Academy of Dermatology.

Marie-France Hivert and colleagues’ article “Dietary fat intake during early pregnancy is associated with cord blood DNA methylation at IGF2 and H19 genes in newborns” is published in Environmental and Molecular Mutagenesis.

June 2021

Marie-France Hivert and colleagues’ article “Diet and erythrocyte metal concentrations in early pregnancy—cross-sectional analysis in Project Viva” is published in The American Journal of Clinical Nutrition.

Maryam Asgari and colleagues’ article “The Need for Critical Examination of Disparities in Immunotherapy and Targeted Therapy Use Among Patients With Cancer” is published in JAMA Oncology.

Christine Lu, former PROMoTeR Fellow Xiaoyan Nie, and colleagues’ article “Genetic variants of PEAR1 and ischemic clinical outcomes in coronary artery disease patients: a systematic review and meta-analysis” is published in Future Medicine Pharmacogenomics.

Marie-France Hivert and colleagues’ article “Physical Activity as a Critical Component of First-Line Treatment for Elevated Blood Pressure or Cholesterol: Who, What, and How?: A Scientific Statement From the American Heart Association” is published in Hypertension.

Maryam Asgari and colleagues’ article “Guidelines of Care for the Management of Actinic Keratosis: Executive Summary” is published in Journal of the American Academy of Dermatology.

Lauren Galbraith, Kurt Christensen, and colleagues’ article “Primary care providers’ responses to unsolicited Lynch syndrome secondary findings of varying clinical significance” is published in Genetics in Medicine.

Collaborator Jennifer Yeh, PhD is futured on this month’s episode of GenePod hosted by Genetics in Medicine. This episode discusses the use of universal newborn screening to identify pediatric cancer predisposition, highlighting work from the PreEMPT project lead by PROMoTeR Director, Ann Wu.

Marie-France Hivert and colleagues’ article “Early pregnancy essential and non-essential metal mixtures and gestational glucose concentrations in the 2nd trimester: Results from Project Viva” is published in Environment International.

Maryam Asgari and colleagues’ article “Vitamin D deficiency exacerbates UV/endorphin and opioid addiction” is published in Science Advances.

Marie-France Hivert and colleagues’ article “Early pregnancy exposure to metal mixture and birth outcomes – A prospective study in Project Viva” is published in Environmental International.

Sharon Lutz and colleagues’ article “Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain” is published in Genetic Epidemiology.

Amy Han, MPH, Project Manager

Haley Sullivan, PhD Summer Student

Natalia Kunst, Research Fellow

Special thanks to Diana Juvinao-Quintero for presenting at the June PROMoTeR Seminar. Diana presented “Using DNA methylation to understand how maternal glycemia in pregnancy may influence future risk of adverse health outcomes in the offspring”.

May 2021

Joanne Sordillo, Sharon Lutz, Ann Wu, and colleagues’ article “Pharmacogenetic Polygenic Risk Score for Bronchodilator Response in Children and Adolescents with Asthma: Proof-of-Concept” is published in Journal of Personalized Medicine.

Published in Precision Oncology News, “Researchers Weigh Benefits, Costs of Screening Newborns for Cancer Risk Mutations” references a Genetics in Medicine article showcasing results from the Precision Medicine Policy and Treatment (PreEMPT) Model led by PROMoTeR Director Ann Wu.

Chris Lu and colleagues’ article “Impact of High-Deductible Health Plans on Medication Use Among Individuals With Bipolar Disorder” is published in Psychiatric Services.

Chris Lu and colleagues’ article “Randomized prospective evaluation of genome sequencing versus standard-of-care as a first molecular diagnostic test” is published in Genetics in Medicine.

Sharon Lutz, Ann Wu, and colleagues’ article “Caution against examining the role of reverse causality in Mendelian Randomization” is published in Genetic Epidemiology.

Kurt Christensen, PhD presented at the May CHeRP Seminar. Dr. Christensen presented “The costs of population genetic screening”

In May, PROMoTeR hosted Dr. Merry-Lynn McDonald, Director of Integrative 'Omics at UAB Division of Pulmonary, Allergy, and Critical Care Medicine for our May PROMoTeR Seminar. Dr. McDonald presented “Genetics of  Musculoskeletal Diseases”.

Congratulations to PROMoTeR Director, Ann Wu who is the recipient of this year’s DPM Gordon Moore Award for Excellence in Mentoring!

April 2021

Kurt Christensen, Lauren Galbraith, Jessica LeBlanc, Emilie Zoltick and colleagues’ article “Precision Population Medicine in Primary Care: The Sanford Chip Experience is published in Frontiers in Genetics.

Marie-France Hivert, Joanne Sordillo, and colleagues’ article “DNA methylation architecture of the ACE2 gene in nasal cells of children” is published in Scientific Reports.

Sharon Lutz and colleagues’ article “Multi‐omics analyses implicate EARS2 in the pathogenesis of atopic dermatitis” is published in Allergy.

Chris Lu and colleagues’ article “Pharmacogenomic Biomarkers in US FDA-Approved Drug Labels (2000–2020)” is published in Journal of Personalized Medicine.

Chris Lu and colleagues’ article “African American Nurses’ Perspectives on Genomic Medicine Research” is published in AMA Journal of Ethics.

Marie-France Hivert and colleagues’ article “Maternal Dietary Inflammatory Index in Pregnancy and Offspring Behavioral Problems in Mid-Childhood and Early Adolescence” is published in Biological Psychiatry.

Maryam Asgari and colleagues’ article “Guidelines of care for the management of actinic keratosis” is published in Journal of the American Academy of Dermatology.

Marie-France Hivert, Joanne Sordillo, and colleagues’ article “Cesarean delivery and metabolic health and inflammation biomarkers during mid-childhood and early adolescence” is published in Pediatric Research.

Marie-France Hivert and colleagues’ article “Longitudinal associations of fruit juice intake in infancy with DXA-measured abdominal adiposity in mid-childhood and early adolescence” is published in The American Journal of Clinical Nutrition.

Chris Lu and colleagues’ article “Out-of-Pocket Spending Inequity Among High-Deductible Health Plan Members with Bipolar Disorder” is published in Journal of General Internal Medicine.

Ann Wu and Kurt Christensen are named investigators/contributors on the Precision Population Health initiative launched through Ariadne Labs & Genomes2People.

Ann Wu and colleagues’ article “Association of Oral Corticosteroid Bursts With Severe Adverse Events in Children” is published in JAMA Pediatrics.

Sharon Lutz and colleagues’ article “A fast and efficient smoothing approach to Lasso regression and an application in statistical genetics: polygenic risk scores for chronic obstructive pulmonary disease (COPD)” is published in Statistics and Computing.

Marie-France Hivert, Joanne Sordillo and colleagues’ article “Residential PM 2.5 exposure and the nasal methylome in children” is published in Environment International.

Chris Lu and colleagues’ paper “Weighing the Association Between BMI Change and Suicide Mortality” is published in Psychiatric Services.

Kurt Christensen presented “Population Genetic Screening: expectations and process outcomes” at a recent DPM Brown Bag Seminar.

March 2021

Marie-France Hivert and colleagues’ article “DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts” is published in Clinical Epigenetics.

Marie-France Hivert and colleagues’ article “Per- and polyfluoroalkyl substances and calcifications of the coronary and aortic arteries in adults with prediabetes: Results from the diabetes prevention program outcomes study” is published in Environmental International.

Marie-France Hivert and colleagues’ article “Detecting differentially methylated regions with multiple distinct associations” is published in Future Medicine Epigenomics.

Director Ann Wu was one of the theme coordinators for the March issue of The Journal of Allergy of Clinical Immunology: In Practice.

Ann Wu, MD, MPH, was a theme coordinator for the March 2021 issue.

Marie-France Hivert and colleagues’ article “Comparative epigenome-wide analysis highlights placenta-specific differentially methylated regions” is published in Future Medicine Epigenomics.

Director Ann Wu and colleagues’ article “Biologic Therapy in Allergy Practice: A New Era in Treatment Has Begun” is published in The Journal of Allergy and Clinical Immunology: In Practice.

Ann Wu, Chris Lu, Kurt Christensen, Pamela McMahon, and colleagues’ article “Universal newborn genetic screening for pediatric cancer predisposition syndromes: model-based insights” is published in Genetics in Medicine.

February 2021

Marie-France Hivert and colleagues’ article “A prospective study of maternal adiposity and glycemic traits across pregnancy and mid-childhood metabolomic profiles” is published in International Journal of Obesity.

Marie-France Hivert and colleagues’ article “Separating Algorithms from Questions and Causal Inference with Unmeasured Exposures: An Application to Birth Cohort Studies of Early BMI Rebound” is published in American Journal of Epidemiology.

In February PROMoTeR hosted Dr. Stephen Kingsmore - President and Chief Executive Officer, Rady Children’s Institute for Genomic Medicine as this year’s PROMoTeR Center Visiting Professor. Dr. Kingsmore presented “Rapid whole genome sequencing in newborns for rare diseases”

January 2021

Marie-France Hivert and colleagues’ article “Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation” is published in Molecular Psychiatry.

Marie-France Hivert and colleagues’ article “Epigenome-wide association study of maternal hemoglobin A1c in pregnancy and cord blood DNA methylation” is published in Epigenomics.

Ann Wu and colleagues’ article “Pharmacogenetics of inhaled corticosteroids and exacerbation risk in adults with asthma” is published in Clinical & Experimental Allergy.

Marie-France Hivert and colleagues’ article “Per- and polyfluoroalkyl substances and kidney function: Follow-up results from the Diabetes Prevention Program trial” is published in Environmental International.

Marie-France Hivert and colleagues’ article “Neighborhood Child Opportunity Index and Adolescent Cardiometabolic Risk” is published in Pediatrics.

Kirsten Voorhies, Joanne Sordillo, Sharon Lutz, Ann Wu, and colleagues’ article “Age by Single Nucleotide Polymorphism Interactions on Bronchodilator Response in Asthmatics” is published in Journal of Personalized Medicine.

In January, PROMoTeR hosted Dr. Ofer Levy, Director of the Precision Vaccine Program at Boston Children’s Hospital. Dr. Levy presented “Precision Vaccines: Bringing Precision Medicine to Vaccinology”.