TIDE Research


TIDE's body of work spans two primary focus areas: Therapeutics and Infectious Disease Epidemiology.

Therapeutics Research

Determining the effectiveness of marketed drugs and vaccines, ensuring their safety, and improving the appropriateness of their use are longstanding, important societal challenges. Current activities focus on development of new knowledge, and of better local and national capabilities to perform collaborative research. We lead several distributed data networks to support therapeutics research and surveillance programs.

Please click on the links below to learn more about our ongoing Therapeutics Research projects.


Sentinel is a national medical product monitoring system.


PopMedNet is a software platform that facilitates the creation, operation, and governance of distributed health data networks.

NIH Collaboratory

Health Care Systems Research Collaboratory

Patient-Centered Outcomes Research Network (PCORnet)

Develop, refine, and apply analytic methods that perform sophisticated statistical analyses without sharing of potentially identifiable patient-level information.

Privacy-Protecting Methods

Developing and applying cutting-edge analytic and data-sharing methods that integrate epidemiology, biostatistics, data science, and informatics to improve the validity, feasibility, and efficiency of multi-center studies, particularly in distributed data network studies that leverage routinely collected electronic health data.

The Biologics and Biosimilars Collective Intelligence Consortium (BBCIC)

A non-profit, scientific public service initiative that will monitor biosimilars and corresponding novel biologics for effectiveness and safety.

Infectious Disease Epidemiology Research

The TIDE group leads several programs based on public-private partnerships between academic centers, health care organizations, and the traditional public health community focusing on the identification and reporting of notifiable infectious diseases. Our ongoing initiatives aim to enhance surveillance, reporting, prevention, and management of serious infections in hospitals and communicable diseases within the broader population.

Please click on the links below to learn more about our ongoing Infectious Disease Epidemiology Research projects.

Harvard-UCI Prevention Epicenter

Promoting new ways to address problems such as reducing the burden of healthcare-associated infections and antibiotic resistance.

ESP/MDPHnet Projects

Development of an open source software application that uses EHR data to conduct public health surveillance on the individual level for notifiable diseases and in aggregate for other conditions of interest to the public.


Provides healthcare epidemiology prevention Research, Implementation, Evaluation, Surveillance, and Medication Studies.

ABATE Infection Project (NIH Collaboratory Demonstration Project)

A pragmatic clinical trial that evaluates the impact of decolonization on healthcare associated infections in the general patient population outside Intensive Care Units.

National Claims-Based Quality Measures for Surgical Site Infections

Developing validated quality measures for inter-hospital comparisons of healthcare associated infections such as surgical site infections.