Examples of Current CarPE Research Projects
|High Resolution Measures of Behavioral Cancer Risk Factors from Mobile Technology|
CarPE Investigator(s): Peter James | Funder: National Cancer Institute
This study aims to accurately measure the interdependent relationships between geographic context, physical activity, sleep, and obesity within a subsample (n=300) of the Nurses' Health Study 3 (NHS3), a web-based, nationwide prospective open cohort with a current enrollment of ~40,000 male and female nurses aged 19-46 years old.
|Precision Medicine Policy and Treatment (PreEMPT) Model|
CarPE Investigator(s): Ann Wu, Christine Lu, Natasha Stout | Funder: National Institute of Child Health and Human Development
The goal is to project clinical and economical outcomes associated with alternative strategies to assess the potential value of genomic technologies for newborn screening with examples of cancer and cardiology.
|Implementation Science Center in Cancer Control Equity: A Competitive Revision to Accelerate COVID Testing in Vulnerable Communities|
CarPE Investigator(s): Julia Marcus | Funder: National Cancer Institute
The goal of this study is to partner with the Massachusetts League of Community Health Centers to build an infrastructure that will support future COVID-related efforts in the vulnerable communities that these community health centers serve.
|A Conversation Aid to Support Shared Decision Making between Women Aged 75 and Older and their Clinicians on Mammography|
CarPE Investigator(s): Natasha Stout, Eeva-Liisa Rossell Johansen | Funder: National Institute on Aging
The goal of this project is for an interdisciplinary team of geriatricians, internists, computer programmers, decision analysts and communications researchers, the American College of Physicians (ACP), and the Cancer Intervention and Surveillance Network (CISNET) to develop an innovative multi-level web-based decision support tool for clinicians and women >75 years to use during an office visit to improve shared decision making around mammography screening.
|Advanced Breast Imaging: Trends and Outcomes Associated with Recent Breast Density Reporting Legislation|
CarPE Investigator(s): Natasha Stout, Dennis Ross-Degnan, J. Frank Wharam, Fang Zhang| Funder: National Cancer Institute
This project is evaluating the impact of state-specific density notification legislation on use of breast imaging and downstream clinical and economic outcomes including breast cancer incidents.
|Risk-Based Breast Cancer Screening in Community Settings and Surveillance in Community Practice|
CarPE Investigator(s): Natasha Stout, Eeva-Liisa Rossell Johansen | Funder: National Cancer Institute
A renewal of P01CA154292, this research conducted by members of the Breast Cancer Surveillance Consortium, consists of three projects supported by two cores that will identify tomosynthesis and multi-modality screening outcomes by examining women, radiologist, and facility factors.
|Comparative Effectiveness of Breast Cancer Screening, Diagnosis, and Management in Community Practice |
CarPE Investigator(s): Natasha Stout | Funder: PCORI
This research conducted by members of the Breast Cancer Surveillance Consortium seeks to provide information on the benefits and harms of screening modalities tailored according to extent of breast density and about the comparative effectiveness of preoperative breast imaging with MRI (vs. no MRI) by breast density.
|Identifying Effective Risk-based Supplemental Ultrasound Screening Strategies for Women with Dense Breasts|
CarPE Investigator(s): Natasha Stout | Funder: PCORI
This study will comprehensively evaluate screening ultrasound performance in clinical practice using prospectively collected data from the Breast Cancer Surveillance Consortium and computer simulation modeling to project long term outcomes.
|Implementing Universal Lynch Syndrome Screening Across Multiple Health Care Systems: Identifying Strategies to Facilitate and Maintain Programs in Different Organizational Contexts|
CarPE Investigator(s): Christine Lu | Funder: National Cancer Institute
The overarching goal of this project is to create an organization-level toolkit for implementing, maintaining, and improving Lynch Syndrome screening by using tools from implementation science to describe, explain, and compare decision making and other variations in screening implementation across multiple healthcare systems.
|Oral Targeted Anticancer Medication Trends and Modifiable Use Predictors|
CarPE Investigator(s): Anita Wagner, Dipal Nagda, Mei-Sing Ong, Dennis Ross-Degnan, Mahnum Shahzad, Frank Wharam, Fang Zhang | Funder: American Cancer Society
The goal of this study is to investigate how pharmaceutical benefit policies affect oral targeted anticancer medication utilization and spending, and to identify patient- and provider-related factors associated with treatment access.
|Comparative Modeling of Precision Breast Cancer Control Across the Translational Continuum|
CarPE Investigator(s): Natasha Stout | Funder: National Cancer Institute
This study by the Cancer Intervention and Surveillance Network (CISNET) will test approaches for implementing precision screening by assessing the population impact of emerging precision treatment paradigms.
|Surveillance for Outcomes of Genomic Medicine Policies|
CarPE Investigator(s): Christine Lu | Funder: National Human Genome Research Institute
Using coverage of next-generation sequencing for patients with late stage or recurrent cancers, this project will advance the field of genomic medicine by developing and validating analytical methods for efficient, rigorous evaluation of policies that impact access to genomic tests and associated outcomes to inform healthcare and policy decisions.
|Geographic Variation in Access to Cancer Care Resources: Patterns and Impacts on Patient Healthcare|
CarPE Investigator(s): Mahnum Shahzad, Anita Wagner | Funder: Pyle Fellowship
This project seeks to examine the interaction between cancer health services resources availability and cancer care processes to improve understanding overall determinants of cancer care and better design interventions to provide cancer care access to vulnerable populations.
|Developing a Model for a Joint Provider-Payer Strategy to Increase Use of Home-based Palliative Care|
CarPE Investigator(s): Anita Wagner | Funder: Harvard Medical School/Ariadne Labs
This initiative will develop, in two phases, a novel payer-provider collaboration to support population-level identification of cancer patients for serious illness conversations and conduct of such conversations.