Developing a Program to Educate Sensitize Caregivers to Reduce the Inappropriate prescription Burden In Elderly with Alzheimer's Disease study (D-PRESCRIBE-AD, NIA R61AG069794 ) is a pragmatic trial of a planned 22,500 individuals with Alzheimer's disease or related dementias in the community. It examines the effect of a provider and patient/caregiver-centered educational intervention on inappropriate prescribing, which includes the use of medications that may no longer be necessary or that may increase the risk of harm. PI: Jerry Gurwitz; HPHCI PI: Rich Platt.  Funded on 9/30/2020, with potential for an additional 4 years of funding if approved for an R33 phase.

Richard Platt, MD, MSc

The Harvard Pilgrim Health Care Institute Department of Population Medicine (PI: Jeffrey Brown) was recently awarded a 22 month contract with GlaxoSmithKline  to study the use of selected medications during pregnancy. This multi-site study uses health plan claims data and claims data linked to electronic health record data to identify and characterize women exposed to Nucala (mepolizumab) and Benlysta (belimumab) during pregnancy specifically, and more generally among women of child-bearing years.  The project will also evaluate the potential of these data for conducting comparative studies between women who were exposed and women who were not exposed to these products during pregnancy.

Dr. Jeffrey Brown was awarded a three-month contract with GlaxoSmithKline (GSK) titled, Shingrix Pregnancy Exposure Study (Preparatory Activities) in June 2020. The goal of this contract is to provide GSK with recommendations for the design and conduct of their planned monitoring study.

Jeffrey Brown, PhD


Julia Marcus, PhD

Dr. Julia Marcus presented on March 6, 2019 at the Annual Conference on Retroviruses and Opportunistic Infections (CROI 2019) in Seattle, WA. Her presentation titled "Using EHR Data to Identify Potential PrEP Candidates in a Large Health Care System" described a prediction model to identify patients at risk of HIV acquisition in Kaiser Permanente Northern California.