Vaccination (Safety, Delivery, Efficacy)

Center researchers are leaders in the nation’s two premier programs for active monitoring of the safety of licensed vaccines: the FDA Post-Licensure Rapid Immunization Safety Monitoring (PRISM) program, part of the FDA Mini-Sentinel program, and the CDC Vaccine Safety Datalink project. Center investigators have also led major studies to address the problems of antibiotic resistance related to vaccination.  Examples of projects include:

  • Monitoring H1N1 influenza vaccine safety and the risk for Guillain-Barre syndrome
  • Studying the risk of febrile seizures after measles-mumps-rubella-varicella vaccine and after concomitant influenza and PCV13 vaccines
  • Developing a framework for studying vaccine safety in pregnant women using health plan, birth registry and fetal death registry data
  • Establishing the data and methodologic infrastructure for active surveillance of vaccine and drug safety
  • The Study of Pneumococcal Antibiotic Resistance in Children (SPARC), one of the largest longitudinal studies of colonization with pneumococcus, a major cause of disease in children worldwid.  It includes investigations of the impact of newly introduced vaccines on carriage, disease, and resistance, as well as genetic analyses of this rapidly adapting organism with important ramifications for human health. 

Related News and Recent Publications

For more information on the Center's work please contact Ryan Walsh