Age 16 years
PROBIT Home | 0 - 12 months | 6.5 years | 11.5 years | 16 years | Publications | Collaborate
September 2012 - July 2015
When the participants were approximately 16 years of age, researchers collected data on growth, adiposity, blood pressure, neurocognitive function, vision, eczema and lung function. A total of 13,557 adolescents (82%) participated.
Intention to treat analyses of the 16-year data demonstrated that the randomized intervention was associated with reduced flexural dermatitis risk among children in the intervention group at 16 years; we saw no detectable effect on lung function or in a questionnaire-derived measures of asthma in this setting, where allergic diseases are rare (Flohr et al, Jama Pediatr, 2017). Children in the intervention group had slightly statistically significantly higher neurocognitive scores for verbal function and memory than children in the control group (Yang et al, PLoS Med, 2018). There was no difference in rates of low vision (Owen et al, Invest Opthalmol Vis Sci, 2018). Risk for obesity was in fact slightly higher in the intervention compared with the control infants, contrary to hypothesis (Martin et al, JAMA Pediatr, 2017).
Principal Investigators, 2012 - 2015
Michael Kramer, MD: McGill University, Quebec, Canada
Richard M. Martin, B.Med.Sci., B.M., B.S., M.Sc., M.R.C.G.P., PhD: University of Bristol, United Kingdom
Emily Oken, MD, MPH: Harvard Pilgrim Health Care Institute, United States of America
Collaborators, 2012 - 2015
Belarus: Konstantin Vichuck, MD; Natalia Bogdanovich, MD, Mikhail Hameza, BA
Canada: Seungmi Yang, PhD
United Kingdom: Carsten Flohr, MD, PhD; John Henderson, MD; Chris Owen, PhD
2012 - 2015 Study Documentation
Selected Publications
- Effects of Promoting Long-term, Exclusive Breastfeeding on Adolescent Adiposity, Blood Pressure, and Growth Trajectories: A Secondary Analysis of a Randomized Clinical Trial
- Effect of an Intervention to Promote Breastfeeding on Asthma, Lung Function, and Atopic Eczema at Age 16 Years: Follow-up of the PROBIT Randomized Trial
- Breastfeeding during infancy and neurocognitive function in adolescence: 16-year follow-up of the PROBIT cluster-randomized trial
- The Effect of Longer-Term and Exclusive Breastfeeding Promotion on Visual Outcome in Adolescence
Bottom Row, L to R: Natalia Bogdanovich, MD, and study staff, 2015 | PROBIT IV pediatricians, 2015 | Natalia Bogdanovich, MD, with a certificate of appreciation for her work on the PROBIT study, presented by Emily Oken